Prefoldin subunit 3 (VBP-1),[1] also Von Hippel–Lindau binding protein 1, is a prefoldin chaperone protein that binds to von Hippel–Lindau protein and transports it from perinuclear granules to the nucleus or cytoplasm inside the cell.[2] It is also involved in transporting nascent polypeptides to cytosolic chaperonins for post-translational folding.[3]
| Prefoldin subunit 3 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | VBP1 | ||||||
| NCBI gene | 7411 | ||||||
| HGNC | 12662 | ||||||
| OMIM | 300133 | ||||||
| RefSeq | NM_003372 | ||||||
| UniProt | P61758 | ||||||
| Other data | |||||||
| Locus | Chr. X q28 | ||||||
| |||||||
VBP-1 is a 197–amino acid heterohexamer comprising two prefoldin-α and four prefoldin-β subunits,[3] and is a member of the prefoldin-α subunit family.[4] It is ubiquitously expressed in tissues, and is located in the cell nucleus and cytoplasm.[4] The VBP1 gene is located at Xq28.[5] Homologues are known to exist between human VBP-1 and proteins in mice, Drosophila and C. elegans.[3]
See also
editReferences
edit- ^ "UniProt". beta.uniprot.org. Retrieved 27 March 2022.
- ^ Tsuchiya H, Iseda T, Hino O (1996). "Identification of a novel protein (VBP-1) binding to the von Hippel–Lindau (VHL) tumor suppressor gene product". Cancer Research. 56 (13): 2881–5. PMID 8674032.
- ^ a b c "GenAtlas report: VBP1". 2003-01-17. Retrieved 2007-07-17.
- ^ a b "NiceProt report: P61758 (Prefoldin 3, human)". 2007-07-10. Retrieved 2007-07-17.
- ^ Brinke A, Green PM, Giannelli F (1997). "Characterization of the gene (VBP1) and transcript for the von Hippel–Lindau binding protein and isolation of the highly conserved murine homologue". Genomics. 45 (1): 105–12. doi:10.1006/geno.1997.4902. PMID 9339366.
External links
edit- von+Hippel-Lindau+binding+protein+1,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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