WAY-161503 is a full agonist of 5-HT2C receptors (Ki = 3.3 nM for displacement of DOI), ~6-fold less potent at 5-HT2A receptors (Ki = 18 nM) and 20-fold less potent at 5-HT2B receptors (Ki = 60 nM).[1] In functional studies, it stimulates calcium mobilization coupled to 5-HT2C, 5-HT2B, and 5-HT2A receptors with EC50 values of 0.8, 1.8, and 7 nM, respectively.[1] WAY-161503 has been reported to produce dose-dependent decreases in food intake in 24-hour fasted normal Sprague-Dawley rats, diet-induced obese mice, and obese Zucker rats with ED50 values of 1.9, 6.8, and 0.73 mg/kg, respectively.[1]
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| Formula | C11H11Cl2N3O |
| Molar mass | 272.13 g·mol−1 |
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WAY-161503 has been used to examine the role of 5-HT2C receptors in rodent models of depression, locomotor activity, reinforcement, or motivated behaviors.[2][3]
References
edit- ^ a b c Rosenzweig-Lipson S, Zhang J, Mazandarani H, Harrison BL, Sabb A, Sabalski J, et al. (February 2006). "Antiobesity-like effects of the 5-HT2C receptor agonist WAY-161503". Brain Research. 1073–1074: 240–51. doi:10.1016/j.brainres.2005.12.052. PMID 16430874. S2CID 23160473.
- ^ Cryan JF, Lucki I (December 2000). "Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors". The Journal of Pharmacology and Experimental Therapeutics. 295 (3): 1120–6. PMID 11082448.
- ^ Hayes DJ, Mosher TM, Greenshaw AJ (February 2009). "Differential effects of 5-HT2C receptor activation by WAY 161503 on nicotine-induced place conditioning and locomotor activity in rats". Behavioural Brain Research. 197 (2): 323–30. doi:10.1016/j.bbr.2008.08.034. PMID 18805442. S2CID 16911749.
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