Wellcome Centre for Human Genetics
The Wellcome Centre for Human Genetics is a human genetics research centre of the Nuffield Department of Medicine in the Medical Sciences Division, University of Oxford, funded by the Wellcome Trust among others.[1]
 | |
| Parent institution | University of Oxford Wellcome Trust |
|---|---|
| Established | 1994 |
| Director | John Todd |
| Staff | 470 |
| Key people | Yvonne Jones (deputy director) |
| Formerly called | Wellcome Trust Center for Human Genetics |
| Location | Henry Wellcome Building of Genomic Medicine, Oxford |
| Coordinates | 51°45′08″N 1°12′55″W / 51.752248°N 1.215255°W |
| Website | www |
Facilities & resources
editThe centre is located at the Henry Wellcome Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with Anthony Monaco as the director.[2][3]
Within the WHG a number of 'cores' provide services to the researchers:
Oxford Genomics Centre
editThe Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq.[4] They also offer Oxford Nanopore MinION and PromethION sequencing.[4] There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium, Affymetrix and Fluidigm.[5]
Research Computing Core
editThe Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage.[6]
Transgenics
editThe Transgenics Core provides access to genetically modified mice and cell lines.[7]
Cellular Imaging
editCellular Imaging Core provides microscopy facilities including fluorescence microscopy (including Fluorescence Correlation Spectroscopy (FCS), Fluorescence Lifetime Correlation Spectroscopy (FLCS), Fluorescence Lifetime Imaging Microscopy (FLIM), Total Internal Reflection Fluorescence Microscopy (TIRF), Photoactivated Localisation Microscopy (PALM), Spectral Imaging (SI) and Single Particle Tracking (SPT).[8]
Research
editStatistical and population genetics
editThe WHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the 1000 Genomes Project and the International HapMap Project.[9]
References
edit- ^ "Welcome to the WHG". well.ox.ac.uk. Retrieved 21 November 2018.
- ^ Farrar, Steve (2000). "Vanguard digs deep into data at Oxford". Times Higher Education. Retrieved 19 December 2011. [dead link]
- ^ Ramagopalan, S. V. (2008). "Life on top—working@ the Wellcome Trust Centre for Human Genetics: Scotland Yard for DNA detectives". New Biotechnology. 25 (1): 39–45. doi:10.1016/j.nbt.2008.04.007. PMID 18504015.
- ^ a b "Sequencing - Oxford Genomics Centre". Oxford Genomics Centre. Retrieved 1 December 2017.
- ^ "Arrays - Oxford Genomics Centre". Oxford Genomics Centre. Retrieved 1 December 2017.
- ^ DDN Storage (2 November 2016), Making high-performance compute appropriate to population-scale biomedical data, retrieved 1 December 2017
- ^ "Transgenics Core". Retrieved 1 December 2017.
- ^ "Cellular Imaging - Wellcome Trust Centre for Human Genetics". www.well.ox.ac.uk. Retrieved 1 December 2017.
- ^ "Research areas - Wellcome Trust Centre for Human Genetics". www.well.ox.ac.uk. Retrieved 1 December 2017.