Wyle or WYLE may refer to:
- WYLE (FM), a radio station (95.1 FM) licensed to serve Grove City, Pennsylvania, United States
- WYLE (TV), commercial television station in Florence, Alabama
- Wyle Laboratories, provider of specialized engineering, scientific and technical services
- People
- Florence Wyle (1881–1968), American-born Canadian sculptor and designer
- George Wyle (1916–2003),American orchestra leader and composer
- Noah Wyle (born 1971), American actor
- Walter de la Wyle, Bishop of Salisbury from 1263 to 1271