Y box binding protein 1

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene. YBX1 is an RNA binding protein that stabilises messenger RNAs modified with N6-methyladenosine.

YBX1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1H95
Identifiers
Aliases	YBX1, BP-8, CSDA2, CSDB, DBPB, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1, CBF-A, EFI-A, Y-box binding protein 1
External IDs	OMIM: 154030; MGI: 99146; HomoloGene: 88707; GeneCards: YBX1; OMA:YBX1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p34.2 Start 42,682,418 bp End 42,703,805 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 D2.1 Start 119,135,178 bp End 119,151,801 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis ganglionic eminence ventricular zone Achilles tendon gastrocnemius muscle muscle of thigh skeletal muscle tissue left ventricle stromal cell of endometrium Top expressed in Ileal epithelium primitive streak tail of embryo abdominal wall medial ganglionic eminence endothelial cell of lymphatic vessel seminiferous tubule choroid plexus of fourth ventricle migratory enteric neural crest cell maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific RNA polymerase II cis-regulatory region sequence-specific DNA binding protein binding RNA binding nucleic acid binding GTPase binding double-stranded DNA binding single-stranded DNA binding chromatin binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm CRD-mediated mRNA stability complex nuclear membrane intracellular membrane-bounded organelle U12-type spliceosomal complex nucleoplasm extracellular region cytoplasmic stress granule extracellular exosome nucleus histone pre-mRNA 3'end processing complex cytosol ribonucleoprotein complex Biological process CRD-mediated mRNA stabilization mRNA splicing, via spliceosome regulation of transcription, DNA-templated mRNA processing transcription by RNA polymerase II protein localization to cytoplasmic stress granule transcription, DNA-templated positive regulation of cell division positive regulation of transcription by RNA polymerase II in utero embryonic development RNA splicing negative regulation of striated muscle cell differentiation negative regulation of transcription by RNA polymerase II Notch signaling pathway cellular response to interleukin-7 Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4904 22608 Ensembl ENSG00000065978 ENSMUSG00000028639 UniProt P67809 P62960 RefSeq (mRNA) NM_004559 NM_011732 RefSeq (protein) NP_004550 NP_035862 Location (UCSC) Chr 1: 42.68 – 42.7 Mb Chr 4: 119.14 – 119.15 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Clinical significance

YBX1 is a potential drug target in cancer therapy. YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy. Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions

Y box binding protein 1 has been shown to interact with:

• ANKRD2,
• CTCF,
• P53,
• PCNA,
• RBBP6, and
• SFRS9.

Further reading

• Kolluri R, Torrey TA, Kinniburgh AJ (January 1992). "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif". Nucleic Acids Research. 20 (1): 111–116. doi:10.1093/nar/20.1.111. PMC 5356827. PMID 1738588.
• Kolluri R, Kinniburgh AJ (September 1991). "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein". Nucleic Acids Research. 19 (17): 4771. doi:10.1093/nar/19.17.4771. PMC 328725. PMID 1891370.
• Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S (December 1988). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology". Gene. 73 (2): 499–507. doi:10.1016/0378-1119(88)90514-8. PMID 2977358.
• Didier DK, Schiffenbauer J, Woulfe SL, Zacheis M, Schwartz BD (October 1988). "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box". Proceedings of the National Academy of Sciences of the United States of America. 85 (19): 7322–7326. Bibcode:1988PNAS...85.7322D. doi:10.1073/pnas.85.19.7322. PMC 282178. PMID 3174636.
• Kudo S, Mattei MG, Fukuda M (July 1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain". European Journal of Biochemistry. 231 (1): 72–82. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487.
• Lloberas J, Maki RA, Celada A (September 1995). "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins". Molecular and Cellular Biology. 15 (9): 5092–5099. doi:10.1128/mcb.15.9.5092. PMC 230756. PMID 7651426.
• Chen NN, Chang CF, Gallia GL, Kerr DA, Johnson EM, Krachmarov CP, et al. (February 1995). "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element". Proceedings of the National Academy of Sciences of the United States of America. 92 (4): 1087–1091. Bibcode:1995PNAS...92.1087C. doi:10.1073/pnas.92.4.1087. PMC 42642. PMID 7862639.
• Horwitz EM, Maloney KA, Ley TJ (May 1994). "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes". The Journal of Biological Chemistry. 269 (19): 14130–14139. doi:10.1016/S0021-9258(17)36764-9. PMID 8188694.
• Kashanchi F, Duvall JF, Dittmer J, Mireskandari A, Reid RL, Gitlin SD, et al. (January 1994). "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression". Journal of Virology. 68 (1): 561–565. doi:10.1128/JVI.68.1.561-565.1994. PMC 236322. PMID 8254772.
• Makino Y, Ohga T, Toh S, Koike K, Okumura K, Wada M, et al. (May 1996). "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter". Nucleic Acids Research. 24 (10): 1873–1878. doi:10.1093/nar/24.10.1873. PMC 145870. PMID 8657568.
• Funke B, Zuleger B, Benavente R, Schuster T, Goller M, Stévenin J, et al. (October 1996). "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins". Nucleic Acids Research. 24 (19): 3821–3828. doi:10.1093/nar/24.19.3821. PMC 146158. PMID 8871564.
• Koike K, Uchiumi T, Ohga T, Toh S, Wada M, Kohno K, et al. (November 1997). "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation". FEBS Letters. 417 (3): 390–394. Bibcode:1997FEBSL.417..390K. doi:10.1016/S0014-5793(97)01296-9. PMID 9409758. S2CID 24656107.
• Toh S, Nakamura T, Ohga T, Koike K, Uchiumi T, Wada M, et al. (January 1998). "Genomic organization of the human Y-box protein (YB-1) gene". Gene. 206 (1): 93–97. doi:10.1016/S0378-1119(97)00570-2. PMID 9461420.
• Sawaya BE, Khalili K, Amini S (February 1998). "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat". The Journal of General Virology. 79. 79 ( Pt 2) (2): 239–246. doi:10.1099/0022-1317-79-2-239. PMID 9472608.
• Mertens PR, Alfonso-Jaume MA, Steinmann K, Lovett DH (December 1998). "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription". The Journal of Biological Chemistry. 273 (49): 32957–32965. doi:10.1074/jbc.273.49.32957. PMID 9830047.
• Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, et al. (January 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Research. 59 (2): 342–346. PMID 9927044.
• Safak M, Gallia GL, Khalili K (April 1999). "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells". Molecular and Cellular Biology. 19 (4): 2712–2723. doi:10.1128/mcb.19.4.2712. PMC 84064. PMID 10082537.
• Kelm RJ, Cogan JG, Elder PK, Strauch AR, Getz MJ (May 1999). "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter". The Journal of Biological Chemistry. 274 (20): 14238–14245. doi:10.1074/jbc.274.20.14238. PMID 10318844.
• Safak M, Gallia GL, Ansari SA, Khalili K (December 1999). "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen". Journal of Virology. 73 (12): 10146–10157. doi:10.1128/JVI.73.12.10146-10157.1999. PMC 113067. PMID 10559330.
• Ansari SA, Safak M, Gallia GL, Sawaya BE, Amini S, Khalili K (October 1999). "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity". The Journal of General Virology. 80. 80 ( Pt 10) (10): 2629–2638. doi:10.1099/0022-1317-80-10-2629. PMID 10573156.
• Basaki Y, Hosoi F, Oda Y, Fotovati A, Maruyama Y, Oie S, et al. (April 2007). "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells". Oncogene. 26 (19): 2736–2746. doi:10.1038/sj.onc.1210084. PMID 17072343.

External links

• YBX1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.