Yixian may refer to :
- Places and jurisdictions
- Yi County, Anhui, in China
- Yi County, Hebei, in China
- Yi County, Liaoning, in China
- the Latin Catholic Apostolic Prefecture of Yixian, near Beijing and Baoding
- Yi County, Shandong, now Yicheng District, Zaozhuang
- Yixian Formation, a geological formation in Liaoning Province
- Persons
- Empress Yixian, Liang Nüying (died 159), Chinese empress during the Han dynasty