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Yuri Sergeevich Shabarov

Yuri Sergeevich Shabarov (August 5, 1919, Moscow, RSFSR — October 30, 2005, Moscow, Russian Federation) was a Soviet and Russian organic chemist, the founder of arylcyclopropane chemistry, the author of 25 patents for the synthesis of compounds from ortho-substituted arylated cyclopropanes. He is the author or coauthor of many textbooks on organic chemistry.

Yuri Sergeevich Shabarov
Юрий Сергеевич Шабаров
Born(1919-07-05)July 5, 1919
Moscow, RSFSR
DiedOctober 30, 2005(2005-10-30) (aged 86)
Moscow, Russian Federation
EducationMoscow State University, 1948
OccupationScientist
OrganizationMoscow State University
SpouseZoe Shabarova (1950)
ChildrenAlexey Yuryevich Shabarov

Early life and education

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Yuri Shabarov was born on August 5, 1919, in Moscow. He graduated from high school with a gold medal in 1938 and entered the Faculty of Chemistry at Moscow State University (MSU) the same year.

In November 1941, during World War II, Shabarov was conscripted into the Red Army, serving until May 1946 and attaining the rank of senior lieutenant..[1][2] After his military service, Shabarov resumed his studies and graduated with honors from MSU in 1948. He entered the graduate program at the MSU Chemistry Research Institute in October 1948 and defended his PhD thesis in October 1951.[3]

Academic career

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Upon completing his postgraduate studies, Shabarov began his academic career at MSU as a junior researcher. In August 1953, he was appointed acting senior researcher, and by December 1954, he was promoted to senior researcher. In June 1959, Shabarov earned the title of Docent of the Faculty of Chemistry. He defended his doctoral dissertation in 1964. In December 1967, he was appointed acting professor, and in September 1969, he became a full professor at the Faculty of Chemistry.

Yuri Sergeevich also actively engaged in organizational and administrative activities. From 1969 to 1976, he was a member of the Academic Council of the N.D. Zelinsky Institute of Organic Chemistry. Between 1974 and 1985, he served as a member of the Academic Council of the Faculty of Chemistry at Moscow State University, and from 1981 to 1995, he was Deputy Chairman of the Department.

In addition, Shabarov held various positions at the Chemical Department over the years, including Deputy Dean (1954), Chairman of the Admissions Committee (1962–1964), Head of the Organic Chemistry Practicum (1968–1980), Head of the Laboratory of Organic Synthesis (1971–1989), and Deputy Head of the Department of Organic Chemistry (1976–1986). In 1994, he was hired as a consulting professor at the Department of Organic Chemistry and combined it with the position of professor until August 31, 2005.[4]

Research and scientific contributions

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Yuri Sergeevich Shabarov's scientific interests were closely tied to the chemistry of small carbocycles. He was a pioneer in the field of arylated cyclopropane chemistry in Russia, and his work earned widespread recognition internationally. Over his career, Shabarov published more than 350 scientific papers, which highlighted a range of novel and specific reactions of functionally substituted arylcyclopropanes. His research explored the unique properties of three-membered carbocycles with aromatic nuclei, including phenomena such as the cyclopropane ortho effect during nitration, ipso-electrophilic attack on the cyclopropane fragment, and the initiating role of small carbocycles in intramolecular rearrangements and transformations.[5]

Shabarov made significant contributions to both fundamental and applied arylcyclopropane chemistry, widely acknowledged by the scientific community. His studies on fundamental mechanisms included the nitration of arylcyclopropanes, nitrodealkylation, electrophile-catalyzed nucleophilic substitution, proton-catalyzed rearrangements, cyclizations, heterocyclizations, and isomerizations of cyclopropyl-substituted substrates[6]. On the applied side, he developed synthetic methods for functionally substituted arylcyclopropanes and various heterocycles such as benzoxazoles[7], oxazoles, benzoxazines[8], benzodiazepines[9], indoles[10], indazoles, quinolines, and quinolones[11]

Shabarov's research also demonstrated that the reaction patterns observed in the nitration and electrophile-catalyzed transformations of functionally substituted arylcyclopropanes were characteristic of aromatic substrates capable of generating benzyl and homobenzyl carbocations during the reaction.[6]

His work laid the foundation for the study of ortho-substituted arenes, a promising field for the synthesis of various heterocycles, including natural compounds, potential drugs, and biologically active substances. Findings from Shabarov's research—such as the mechanisms of arylcyclopropane reactions with electrophiles, acid-catalyzed rearrangements, and heterocyclizations—have been included in reference materials, review articles, and textbooks authored by both domestic and international scientists.[4]

Yuri Sergeevich obtained 25 inventor's certificates for his innovations, primarily for methods of synthesizing compounds from ortho-substituted arylcyclopropanes[12][13]. Notably, nine of these certificates were classified with the "Not for open publication" restriction by the Committee for Inventions and Discoveries of the USSR. This classification was due to Shabarov's 30 years of collaboration, from 1965 to 1995, with various organizations within the military-industrial complex.

Teaching activity

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Shabarov began his educational activity in 1951. From the very start of his work at the Chemical Department, he actively engaged in student education, leading seminars and practical classes for third-year students and supervising coursework and diploma projects. Between 1964 and 1968, following the defense of his doctoral dissertation, he taught his own course, "Synthetic Methods in Organic Chemistry." On the recommendation of A.N. Nesmeyanov, Head of the Department of Organic Chemistry, Shabarov taught the general course "Organic Chemistry" for 25 years, from 1968 to 1993.

In 1994, the first edition of the two-volume textbook Organic Chemistry[14][15], written by Shabarov and based on his lectures, was published for students of chemistry faculties and higher educational institutions. Due to its popularity, the textbook was reissued three times. It also received high praise from other professors for its comprehensive coverage and logical presentation of fundamental concepts.

From 1994, Shabarov delivered a specialized course, Carbohydrate Chemistry, for students focusing on natural compound chemistry. In 1998, he published the methodological guide Mono– and Disaccharides[16][17], tailored for the specialized course as well as the general curriculum for chemistry students on the topic of natural compounds. Shabarov also co-authored several textbooks and educational materials with faculty members of the Department of Organic Chemistry at Moscow State University, some of which were translated into foreign languages. These include Practical Work in Organic Chemistry, Laboratory Exercises in Organic Practicum, and Problems and Exercises in Organic Chemistry (the latter translated into English and Spanish).[4]

Under Shabarov's supervision, more than 120 diploma theses, 30 candidate dissertations, and two doctoral dissertations (in 1984 and 1992) were successfully defended.[5]

His teaching activities and lectures were highly appreciated both by the faculty and the administration of Moscow State University, as well as by the students, who emphasized Shabarov's lecturing skills, his intelligence and tact in communication, and his ability to avoid conflicts.[18]

Family

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Yuri Shabarov's wife, Zoya Alekseevna Shabarova (1925–1999), was a bioorganic chemist specializing in nucleic acid chemistry. She married him in 1950.

Their son, Alexey Yuryevich Shabarov (b. 1953), holds a PhD in Physics and Mathematics. He worked at the Faculty of Computational Mathematics and Cybernetics at MSU and later became an employee of the Research Institute of Technical Physics and Automation.[19]

Hobbies

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Yuri Sergeevich Shabarov was actively passionate about sports. He held a first-class rank in tennis and shared his enthusiasm with his students. According to accounts, his laboratory sessions often began with a "sports five-minute discussion," where recent sports events were discussed. In addition to sports, Shabarov was fond of painting, graphic arts, and sculpture. Later in life, he also developed interests in philately and fishing.[4]

Award and honors

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Yuri Sergeevich Shabarov received numerous awards and honors throughout his career:

Honorary Titles:

  • "Distinguished Professor of Moscow State University"[22]
  • "Soros Distinguished Professor"[23]

References

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  1. ^ https://chem.msu.ru/rus/vmgu/994/287.pdf
  2. ^ "Шабаров Ю.С. — профиль | ИСТИНА". istina.msu.ru. Retrieved 2024-11-18.
  3. ^ Shabarov, Yu. S. Personal file, Archive of the Chemistry Department, Moscow State University.
  4. ^ a b c d e f http://www.chem.msu.su/rus/vmgu/096/475.pdf
  5. ^ a b "Шабаров Ю.С. — профиль | ИСТИНА". istina.msu.ru. Retrieved 2024-11-18.
  6. ^ a b Mochalov, S.S.; Gazzaeva, R.A.; Fedotov, A.N. (2005). "О превращениях пара-замещенных бензилциклопропанов, аллилбензолов и дифенилметанов в условиях нитрования азотной кислотой в уксусном агнидриде" [On the transformations of para-substituted benzylcyclopropanes, allylbenzenes and diphenylmethanes under nitration with nitric acid in acetic agnidride]. Журнал органической химии. 41 (3): 415–424.
  7. ^ Mochalov, S.S.; Kutateladze, T.G.; Atovmyan, I.L. (1992). "Synthesis of 3,6-dialkyl-4,5-dihydro-4,5-dichloro-2,1-benzisoxazoles from o-nitrophenylcyclopropanes". Chemistry of Heterocyclic Compounds. 28 (1): 112–113. doi:10.1007/BF00529496.
  8. ^ Mochalov, S.S.; Gazzaeva, R.A.; Fedotov, A.N.; Shabarov, Yu.S. "New pathway to the synthesis of substituted 4H-3,1-benzoxazines". Chemistry of Heterocyclic Compounds (6): 922–929.
  9. ^ Mochalov, S.S.; Kosynkin, D.V.; Yudin, I.D. (1994). "Synthesis of 1,3-dihydro-5(R)-7,8-ethylenedihydroxy-2H-1,4-benzodiazepin-2-ones". Chemistry of Heterocyclic Compounds. 30 (5): 601–607. doi:10.1007/BF01169826.
  10. ^ Mochalov, S.S.; Fedotov, A.N.; Yufit, D.S.; Shabarov, Yu.S. (1991). "Novel Rearrangement in the 3-Indolinone Series". Chemistry of Heterocyclic Compounds. 7: 929–932.
  11. ^ Trofimova, E.V.; Fedotov, A.N.; Mochalov, S.S.; Shabarov, Yu.S. (2000). "Acid-catalyzed transformations of N-(4-nitrobenzylidene)-2-cyclopropyl- and N-(4-nitrobenzylidene)-2-alkenylanilines. New route to synthesis of dihydroquinolines and quinolines". Chemistry of Heterocyclic Compounds. 36 (10): 1385–1394. doi:10.1023/A:1002824917758.
  12. ^ "Способ получения 2-нитрозоацилбензолов. - патент | ИСТИНА – Интеллектуальная Система Тематического Исследования НАукометрических данных". istina.msu.ru. Retrieved 2024-11-23.
  13. ^ "Способ получения замещенных 5-фенил-1,2-оксатиолан-2-оксидов - патент | ИСТИНА – Интеллектуальная Система Тематического Исследования НАукометрических данных". istina.msu.ru. Retrieved 2024-11-23.
  14. ^ Shabarov, Yuri Sergeevich (1994). Органическая химия: учебник для студентов вузов, обучающихся по направлению "Химия": часть 1. Нециклические соединения [Organic Chemistry: textbook for university students studying in the field of Chemistry: part 1. Non-cyclic compounds] (in Russian). Moscow: Khimiya. p. 494. ISBN 5-7245-0990-3.
  15. ^ Shabarov, Yuri Sergeevich (1994). Органическая химия: учебник для студентов вузов, обучающихся по направлению "Химия": часть 2. Циклические соединения [Organic Chemistry: textbook for university students studying in the field of Chemistry: part 2. Cyclic compounds] (in Russian). Moscow: Khimiya. p. 846. ISBN 5-7245-0991-1.
  16. ^ Shabarov, Yuri Sergeevich (2010). Моно- и дисахариды, часть 1 [Mono- and disaccharides, part 1] (in Russian) (5th ed.). Moscow: Department of Operational Printing and Information of the Faculty of Chemistry of Moscow State University.
  17. ^ Shabarov, Yuri Sergeevich (2010). Моно- и дисахариды, часть 2 [Mono- and disaccharides, part 2] (in Russian) (5th ed.). Moscow: Department of Operational Printing and Information of the Faculty of Chemistry of Moscow State University.
  18. ^ https://oralhistory.ru/talks/orh-1432.pdf
  19. ^ "Алексей Шабаров - читай онлайн, покупай книги автора в электронном или печатном виде на Ridero". ridero.ru (in Russian). Retrieved 2024-11-18.
  20. ^ "О награждении государственными наградами Российской Федерации от 22 ноября 1999 - docs.CNTD.ru".
  21. ^ "Шабаров Юрий Сергеевич".
  22. ^ "Бессмертный полк химического факультета - Шабаров Юрий Сергеевич".
  23. ^ "Список Заслуженных Соросовских Профессоров и Заслуженных Соросовских Учителей -".

Further reading

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  • Shabarov, Yuri Sergeevich. Органическая химия: Учеб. для студентов вузов обучающихся по направлению "Химия" [Organic Chemistry: A Textbook for University Students in the Field of "Chemistry"] (in Russian) (4th ed.) // Moscow: Khimiya, 2002, 846 pp. ISBN5-7245-1218-1.
  • Shabarov, Alexey Yurievich. Шабаровы: полтора века московской семьи [The Shabarovs: A Century and a Half of a Moscow Family.] (in Russian). // Moscow: ARTKITHEN, 2018, 367 pp. ISBN978-5-905993-12-1.
  • Shabarov, A.Y., Agronomov A.E. Лабораторные работы в органическом практикуме [Laboratory Work in Organic Practical] (in Russian). // Moscow: Moscow University Press, 1971, 230 pp.
  • Shabarov, A.Y., Agronomov A.E. Лабораторные работы в органическом практикуме: Для хим. специальностей вузов [Laboratory Work in Organic Practical: For Chemistry Majors in Universities] (in Russian). // Moscow: Khimiya, 1974, 375 pp.
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