Zinc transporter ZIP1

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Zinc transporter ZIP1 is a protein that in humans is encoded by the SLC39A1 gene.[5][6][7]

SLC39A1
Identifiers
AliasesSLC39A1, ZIP1, ZIRTL, solute carrier family 39 member 1
External IDsOMIM: 604740; MGI: 1353474; HomoloGene: 40906; GeneCards: SLC39A1; OMA:SLC39A1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013901

RefSeq (protein)

NP_038929

Location (UCSC)Chr 1: 153.96 – 153.97 MbChr 3: 90.16 – 90.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

The protein ZIP1 is responsible for the active transport of zinc into prostate cells. In many prostate cancers SLC39A1 is silenced causing prostate cancer cells to be low in zinc.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143570Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052310Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Lioumi M, Ferguson CA, Sharpe PT, Freeman T, Marenholz I, Mischke D, Heizmann C, Ragoussis J (Feb 2000). "Isolation and characterization of human and mouse ZIRTL, a member of the IRT1 family of transporters, mapping within the epidermal differentiation complex". Genomics. 62 (2): 272–80. doi:10.1006/geno.1999.5993. PMID 10610721.
  6. ^ Gaither LA, Eide DJ (Mar 2000). "Functional expression of the human hZIP2 zinc transporter". J Biol Chem. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
  7. ^ "Entrez Gene: SLC39A1 solute carrier family 39 (zinc transporter), member 1".
  8. ^ Costello LC, Franklin RB (2006). "The clinical relevance of the metabolism of prostate cancer; zinc and tumor suppression: connecting the dots". Mol. Cancer. 5: 17. doi:10.1186/1476-4598-5-17. PMC 1481516. PMID 16700911.

Further reading

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