Gamithromycin

Gamithromycin
Clinical data
Trade names	Zactran
Other names	ML-1709460, ML-460
License data	US DailyMed: Gamithromycin;
Routes of; administration	Subcutaneous
Drug class	Macrolide antibiotic
ATCvet code	QJ01FA95 (WHO) ;
Legal status
Legal status	US: ℞-only; EU: Rx-only;
Identifiers
	IUPAC name (2R,3S,4R,5S,8R,10R,11R,12S,13S,14R)-11-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy}-2-ethyl-3,4,10-trihydroxy-13-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy}-3,5,8,10,12,14-hexamethyl-7-propyl-1-oxa-7-azacyclopentadecan-15-one;
CAS Number	145435-72-9;
PubChem CID	59364992;
DrugBank	DB11416;
ChemSpider	28530824;
UNII	ZE856183S0;
KEGG	D06598;
ChEBI	CHEBI:195437;
ChEMBL	ChEMBL2107342;
CompTox Dashboard (EPA)	DTXSID90904260 ;
ECHA InfoCard	100.123.704
Chemical and physical data
Formula	C40H76N2O12
Molar mass	777.050 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES [H][C@@]1(C[C@@](C)(OC)[C@@H](O)[C@H](C)O1)O[C@H]1[C@H](C)[C@@H](O[C@]2([H])O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)N(CCC)C[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)OC(=O)[C@@H]1C;
	InChI InChI=1S/C40H76N2O12/c1-15-17-42-21-22(3)33(44)40(11,48)29(16-2)52-36(46)26(7)32(53-30-20-39(10,49-14)34(45)27(8)51-30)25(6)35(38(9,47)19-23(42)4)54-37-31(43)28(41(12)13)18-24(5)50-37/h22-35,37,43-45,47-48H,15-21H2,1-14H3/t22-,23+,24+,25-,26+,27-,28-,29+,30-,31+,32-,33+,34-,35+,37-,38+,39+,40+/m0/s1; Key:VWAMTBXLZPEDQO-UZSBJOJWSA-N;

Gamithromycin, sold under the brand name Zactran, is a veterinary medication used for the treatment of cattle, pigs, and sheep.^[3]^[4]^[5] It is a macrolide antibacterial.^[3]^[4] It is a 7a-azalide.^[6]

It was approved for veterinary use in the European Union in 2008.^[3]^[4]

Veterinary uses

In the EU, gamithromycin is indicated for the treatment and prevention of bovine respiratory disease in cattle, swine respiratory disease in pigs, and infectious pododermatitis (foot rot) in sheep.^[3]^[4]^[6]

In the US, gamithromycin is indicated for the treatment of bovine respiratory disease in cattle.^[1]

References

^ ^a ^b "Zactran - gamithromycin injection, solution". DailyMed. 17 April 2024. Retrieved 29 June 2024.
^ "Zactran". U.S. Food and Drug Administration (FDA). Retrieved 29 June 2024.
^ ^a ^b ^c ^d ^e "Zactran EPAR". European Medicines Agency. 1 August 2008. Retrieved 29 June 2024.
^ ^a ^b ^c ^d ^e "Zactran PI". Union Register of veterinary medicinal products. 28 July 2008. Retrieved 29 June 2024.
^ Budde JA, McCluskey DM (2023). "Gamithromycin". Plumb's Veterinary Drug Handbook (10th ed.). Tulsa, OK: Educational Concepts, LLC, dba VetMedux. p. 571. ISBN 978-1-394-17220-7.
^ ^a ^b "Gamithromycin". Inxight Drugs. Retrieved 29 June 2024. This article incorporates text from this source, which is in the public domain.

External links

"Gamithromycin (Code C170019)". NCI Thesaurus.

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[Zactran_FDA_label-1] "Zactran - gamithromycin injection, solution". DailyMed. 17 April 2024. Retrieved 29 June 2024.

[2] "Zactran". U.S. Food and Drug Administration (FDA). Retrieved 29 June 2024.

[Zactran_EPAR-3] "Zactran EPAR". European Medicines Agency. 1 August 2008. Retrieved 29 June 2024.

[Zactran_PI-4] "Zactran PI". Union Register of veterinary medicinal products. 28 July 2008. Retrieved 29 June 2024.

[5] Budde JA, McCluskey DM (2023). "Gamithromycin". Plumb's Veterinary Drug Handbook (10th ed.). Tulsa, OK: Educational Concepts, LLC, dba VetMedux. p. 571. ISBN 978-1-394-17220-7.

[Inxight-6] "Gamithromycin". Inxight Drugs. Retrieved 29 June 2024. This article incorporates text from this source, which is in the public domain.

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