Nomegestrol acetate/estradiol (NOMAC-E2), sold under the brand names Naemis and Zoely among others, is a fixed-dose combination medication of nomegestrol acetate, a progestogen, and estradiol, an estrogen, which is used in menopausal hormone therapy and as a birth control pill to prevent pregnancy in women.[3] It is taken by mouth.
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| Combination of | |
|---|---|
| Nomegestrol acetate | Progestogen |
| Estradiol | Estrogen |
| Clinical data | |
| Trade names | Zoely |
| Other names | NOMAC-E2, NOMAC/E2, MK-8175A |
| AHFS/Drugs.com | UK Drug Information |
| Routes of administration | By mouth |
| Drug class | Estrogen; Progestogen |
| ATC code | |
| Legal status | |
| Legal status | |
| Identifiers | |
| CAS Number | |
| PubChem CID | |
| KEGG | |
Research
editEstradiol-containing birth control pills like NOMAC-E2 may have a lower risk of venous thromboembolism than birth control pills containing ethinylestradiol.[4] This is being studied in the case of NOMAC-E2.[4][5]
See also
editReferences
edit- ^ "Zoely 2.5 mg/1.5 mg film-coated tablets - Summary of Product Characteristics (SmPC)". (emc). 20 July 2020. Retrieved 9 June 2021.
- ^ "Zoely EPAR". European Medicines Agency (EMA). 17 September 2018. Retrieved 9 June 2021.
- ^ Yang LP, Plosker GL (October 2012). "Nomegestrol acetate/estradiol: in oral contraception". Drugs. 72 (14): 1917–28. doi:10.2165/11208180-000000000-00000. PMID 22950535. S2CID 44335732.
- ^ a b Douxfils J, Morimont L, Bouvy C (October 2020). "Oral Contraceptives and Venous Thromboembolism: Focus on Testing that May Enable Prediction and Assessment of the Risk". Semin Thromb Hemost. 46 (8): 872–886. doi:10.1055/s-0040-1714140. PMID 33080636. S2CID 224821517.
- ^ "Results from large-scale real-world safety study for oral combination contraception pill, Zoely (NOMAC-E2), submitted to European Medicines Agency". Theramex (Press release). 27 April 2021. Retrieved 9 June 2021.
External links
edit- "Estradiol mixture with nomegestrol acetate". Drug Information Portal. U.S. National Library of Medicine.
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