(+)-T-muurolol synthase

(+)-T-Muurolol synthase (EC 4.2.3.98) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, (+)-T-muurolol-forming).[1] This enzyme catalyses the following chemical reaction

(+)-T-muurolol synthase
Identifiers
EC no.4.2.3.98
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
(2E,6E)-farnesyl diphosphate + H2O (+)-T-muurolol + diphosphate

The cyclization mechanism involves an intermediate nerolidyl diphosphate.

References

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  1. ^ Hu Y, Chou WK, Hopson R, Cane DE (January 2011). "Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases". Chemistry & Biology. 18 (1): 32–7. doi:10.1016/j.chembiol.2010.11.008. PMC 3034312. PMID 21276937.
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