(+)-camphene synthase (EC 4.2.3.116) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase [cyclizing, (+)-camphene-forming].[1][2][3][4] This enzyme catalyses the following chemical reaction
| (+)-camphene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.116 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Cyclase I of Salvia officinalis (sage) gives about equal parts (+)-camphene and (+)-alpha-pinene.
References
edit- ^ Gambliel H, Croteau R (January 1984). "Pinene cyclases I and II. Two enzymes from sage (Salvia officinalis) which catalyze stereospecific cyclizations of geranyl pyrophosphate to monoterpene olefins of opposite configuration". The Journal of Biological Chemistry. 259 (2): 740–8. PMID 6693393.
- ^ Croteau R, Satterwhite DM, Cane DE, Chang CC (July 1988). "Biosynthesis of monoterpenes. Enantioselectivity in the enzymatic cyclization of (+)- and (–)-linalyl pyrophosphate to (+)- and (–)-pinene and (+)- and (–)-camphene". The Journal of Biological Chemistry. 263 (21): 10063–71. PMID 3392006.
- ^ Wagschal KC, Pyun HJ, Coates RM, Croteau R (February 1994). "Monoterpene biosynthesis: isotope effects associated with bicyclic olefin formation catalyzed by pinene synthases from sage (Salvia officinalis)". Archives of Biochemistry and Biophysics. 308 (2): 477–87. doi:10.1006/abbi.1994.1068. PMID 8109978.
- ^ Pyun HJ, Wagschal KC, Jung DI, Coates RM, Croteau R (February 1994). "Stereochemistry of the proton elimination in the formation of (+)- and (–)-alpha-pinene by monoterpene cyclases from sage (Salvia officinalis)". Archives of Biochemistry and Biophysics. 308 (2): 488–96. doi:10.1006/abbi.1994.1069. PMID 8109979.
External links
edit- (+)-camphene+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
