(+)-Epicubenol synthase (EC 4.2.3.64, farnesyl pyrophosphate cyclase) is an enzyme with systematic name (2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-epicubenol-forming).[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| (+)-epicubenol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.64 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (2E,6E)-farnesyl diphosphate + H2O (+)-epicubenol + diphosphate
This enzyme requires Mg2+.
References
edit- ^ Cane DE, Tandon M, Prabhakaran PC (1993). "Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate". J. Am. Chem. Soc. 115 (18): 8103–8106. doi:10.1021/ja00071a023.
- ^ Cane DE, Tandon M (1994). "Biosynthesis of (+)-epicubenol". Tetrahedron Lett. 35 (30): 5355–5358. doi:10.1016/s0040-4039(00)73498-8.
- ^ Cane DE, Tandon M (1995). "Epicubenol synthase and the stereochemistry of the enzymatic cyclization of farnesyl and nerolidyl diphosphate". J. Am. Chem. Soc. 117 (20): 5602–5603. doi:10.1021/ja00125a029.
- ^ Nabeta K, Kigure K, Fujita M, Nagoya T, Ishikawa T, Okuyama H, Takasawa T (1995). "Bioynthesis of (+)-cubenene and (+)-epicubenol by cell-free extracts of cultured cells of Heteroscyphus planus and cyclization of [2H]farnesyl diphosphates". J. Chem. Soc., Perkin Trans. 1 (15): 1935–1939. doi:10.1039/p19950001935.
- ^ Nabeta K, Fujita M, Komuro K, Katayama K, Takasawa T (1997). "In vitro biosynthesis of cadinanes by cell-free extracts of cultured cells of Heteroscyphus planus". J. Chem. Soc., Perkin Trans. 1 (14): 2065–2070. doi:10.1039/a701145h.
External links
edit- (+)-epicubenol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
