(Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase (EC 2.1.1.246, methyltransferase 2, mtaA (gene)) is an enzyme with systematic name methylated methanol-specific corrinoid protein:coenzyme M methyltransferase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
| (Methyl-Co(III) methanol-specific corrinoid protein):coenzyme M methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.246 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M ⇌ methyl-CoM + [Co(I) methanol-specific corrinoid protein]
Free methylcob(I)alamin can substitute for the corrinoid protein in vitro.
References
edit- ^ LeClerc GM, Grahame DA (August 1996). "Methylcobamide:coenzyme M methyltransferase isozymes from Methanosarcina barkeri. Physicochemical characterization, cloning, sequence analysis, and heterologous gene expression". The Journal of Biological Chemistry. 271 (31): 18725–31. doi:10.1074/jbc.271.31.18725. PMID 8702528.
- ^ Harms U, Thauer RK (February 1996). "Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli". European Journal of Biochemistry. 235 (3): 653–9. doi:10.1111/j.1432-1033.1996.00653.x. PMID 8654414.
- ^ Sauer K, Thauer RK (October 1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Zinc dependence and thermodynamics of the methanol:cob(I)alamin methyltransferase reaction". European Journal of Biochemistry. 249 (1): 280–5. doi:10.1111/j.1432-1033.1997.t01-1-00280.x. PMID 9363780.
- ^ Sauer K, Harms U, Thauer RK (February 1997). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri. Purification, properties and encoding genes of the corrinoid protein MT1". European Journal of Biochemistry. 243 (3): 670–7. doi:10.1111/j.1432-1033.1997.t01-1-00670.x. PMID 9057830.
- ^ Sauer K, Thauer RK (May 1999). "Methanol:coenzyme M methyltransferase from Methanosarcina barkeri -- substitution of the corrinoid harbouring subunit MtaC by free cob(I)alamin". European Journal of Biochemistry. 261 (3): 674–81. doi:10.1046/j.1432-1327.1999.00355.x. PMID 10215883.
External links
edit- (methyl-Co(III)+methanol-specific+corrinoid+protein):coenzyme+M+methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
