(RS)-MCPG

(RS)-MCPG is a phenylglycine derivative and a non-selective antagonist of group I and II metabotropic glutamate receptors (mGluRs). It has been used in long-term potentiation (LTP) as well as long-term depression (LTD) research and proved that certain LTP and LTD pathways depend on mGluRs.^[1]^[2] Its full chemical name is (RS)-α-methyl-4-carboxyphenylglycine. It appears as a white solid and its molecular weight is 209.2 Da. Its molecular formula is C₁₀H₁₁NO₄.^[3]

References

^ Bortolotto ZA, Bashir ZI, Davies CH, Collingridge GL (April 1994). "A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation". Nature. 368 (6473): 740–3. Bibcode:1994Natur.368..740B. doi:10.1038/368740a0. PMID 8152485. S2CID 4255573.
^ Otani S, Connor JA (September 1998). "Requirement of rapid Ca2+ entry and synaptic activation of metabotropic glutamate receptors for the induction of long-term depression in adult rat hippocampus". The Journal of Physiology. 511 ( Pt 3) (3): 761–70. doi:10.1111/j.1469-7793.1998.761bg.x. PMC 2231146. PMID 9714858.
^ "(RS)-MCPG". Hello Bio.

[1] Bortolotto ZA, Bashir ZI, Davies CH, Collingridge GL (April 1994). "A molecular switch activated by metabotropic glutamate receptors regulates induction of long-term potentiation". Nature. 368 (6473): 740–3. Bibcode:1994Natur.368..740B. doi:10.1038/368740a0. PMID 8152485. S2CID 4255573.

[2] Otani S, Connor JA (September 1998). "Requirement of rapid Ca2+ entry and synaptic activation of metabotropic glutamate receptors for the induction of long-term depression in adult rat hippocampus". The Journal of Physiology. 511 ( Pt 3) (3): 761–70. doi:10.1111/j.1469-7793.1998.761bg.x. PMC 2231146. PMID 9714858.

[3] "(RS)-MCPG". Hello Bio.

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