1,3-propanediol dehydrogenase

In enzymology, a 1,3-propanediol dehydrogenase (EC 1.1.1.202) is an enzyme that catalyzes the chemical reaction

1,3-propanediol dehydrogenase
Identifiers
EC no.1.1.1.202
CAS no.81611-70-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
propane-1,3-diol + NAD+ 3-hydroxypropanal + NADH + H+

Thus, the two substrates of this enzyme are propane-1,3-diol and NAD+, whereas its 3 products are 3-hydroxypropanal, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is propane-1,3-diol:NAD+ 1-oxidoreductase. Other names in common use include 3-hydroxypropionaldehyde reductase, 1,3-PD:NAD+ oxidoreductase, 1,3-propanediol:NAD+ oxidoreductase, and 1,3-propanediol dehydrogenase. This enzyme participates in ether lipid metabolism as a step in glycerolipid biosynthesis.

References

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  • Abeles RH, Brownstein AM, Randles CH (1960). "beta-Hydroxypropionaldehyde, an intermediate in the formation of 1,3-propanediol by Aerobacter aerogenes". Biochim. Biophys. Acta. 41 (3): 530–1. doi:10.1016/0006-3002(60)90054-8. PMID 13791444.
  • Forage RG, Foster MA (1982). "Glycerol fermentation in Klebsiella pneumoniae: functions of the coenzyme B12-dependent glycerol and diol dehydratases". J. Bacteriol. 149 (2): 413–9. doi:10.1128/JB.149.2.413-419.1982. PMC 216523. PMID 7035429.