11-cis-retinol dehydrogenase (EC 1.1.1.315, RDH5 (gene)) is an enzyme with systematic name 11-cis-retinol:NAD+ oxidoreductase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| 11-cis-retinol dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.315 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 11-cis-retinol---[retinal-binding-protein] + NAD+ 11-cis-retinal---[retinol-binding-protein] + NADH + H+
This enzyme from retinal pigment epithelium, catalyses the reduction of 11-cis-retinol to 11-cis-retinal.
References
edit- ^ Simon A, Hellman U, Wernstedt C, Eriksson U (January 1995). "The retinal pigment epithelial-specific 11-cis retinol dehydrogenase belongs to the family of short chain alcohol dehydrogenases". The Journal of Biological Chemistry. 270 (3): 1107–12. doi:10.1074/jbc.270.3.1107. PMID 7836368.
- ^ Wang J, Chai X, Eriksson U, Napoli JL (February 1999). "Activity of human 11-cis-retinol dehydrogenase (Rdh5) with steroids and retinoids and expression of its mRNA in extra-ocular human tissue". The Biochemical Journal. 338 ( Pt 1): 23–7. doi:10.1042/0264-6021:3380023. PMC 1220019. PMID 9931293.
- ^ Lidén M, Romert A, Tryggvason K, Persson B, Eriksson U (December 2001). "Biochemical defects in 11-cis-retinol dehydrogenase mutants associated with fundus albipunctatus". The Journal of Biological Chemistry. 276 (52): 49251–7. doi:10.1074/jbc.M107337200. PMID 11675386.
- ^ Wu Z, Yang Y, Shaw N, Bhattacharya S, Yan L, West K, Roth K, Noy N, Qin J, Crabb JW (April 2003). "Mapping the ligand binding pocket in the cellular retinaldehyde binding protein". The Journal of Biological Chemistry. 278 (14): 12390–6. doi:10.1074/jbc.M212775200. PMID 12536149.
External links
edit- 11-cis-retinol+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
