16S rRNA (guanine966-N2)-methyltransferase (EC 2.1.1.171, yhhF (gene), rsmD (gene), m2G966 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (guanine966-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
| 16S rRNA (guanine966-N2)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.171 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + guanine966 in 16S rRNA S-adenosyl-L-homocysteine + N2-methylguanine966 in 16S rRNA
The enzyme efficiently methylates guanine966 of the assembled 30S subunits in vitro.
References
edit- ^ Lesnyak DV, Osipiuk J, Skarina T, Sergiev PV, Bogdanov AA, Edwards A, Savchenko A, Joachimiak A, Dontsova OA (February 2007). "Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure". The Journal of Biological Chemistry. 282 (8): 5880–7. doi:10.1074/jbc.m608214200. PMC 2885967. PMID 17189261.
External links
edit- 16S+rRNA+(guanine966-N2)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
