18-Deoxyaldosterone

18-Deoxyaldosterone
Clinical data
Other names	11β,18-epoxy-21-hydroxypregn-4-ene-3,20-dione, 11β-11,18-epoxy-21-hydroxypregn-4-ene-3,20-dione, 11β,18-epoxy-21-hydroxy-progesterone, 21-hydroxy-11β,18-oxido-4-pregnene-3,20-dione
Drug class	Antimineralocorticoid
Identifiers
PubChem CID	188963;
UNII	S4YT68R2XR;
CompTox Dashboard (EPA)	DTXSID30947934 ;
Chemical and physical data
Formula	C21H28O4
Molar mass	344.451 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@@H]4CC5([C@H]3CC[C@@H]5C(=O)CO)CO4;
	InChI InChI=1S/C21H28O4/c1-20-7-6-13(23)8-12(20)2-3-14-15-4-5-16(17(24)10-22)21(15)9-18(19(14)20)25-11-21/h8,14-16,18-19,22H,2-7,9-11H2,1H3/t14-,15-,16+,18-,19+,20-,21?/m0/s1; Key:ZEBLTAXSHAKMDJ-QBSCYWOBSA-N;

18-Deoxyaldosterone is a steroidal antimineralocorticoid with mixed agonist–antagonist but predominantly antagonistic activity at the mineralocorticoid receptor.^[2]

References

^ "(11beta)-11,18-Epoxy-21-hydroxypregn-4-ene-3,20-dione".
^ Duax WL, Griffin JF, Strong PD, Funder JW, Ulick S (1982). "Molecular structure of 18-deoxyaldosterone and its relationship to receptor binding and activity". Journal of the American Chemical Society. 104 (25): 7291–7293. doi:10.1021/ja00389a063. ISSN 0002-7863.

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