2'-Deamino-2'-hydroxyneamine transaminase (EC 2.6.1.94, kacL (gene)) is an enzyme with systematic name 2'-deamino-2'-hydroxyneamine:2-oxoglutarate aminotransferase.[1] This enzyme catalyses the following chemical reaction
| 2'-Deamino-2'-hydroxyneamine transaminase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.6.1.94 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2'-deamino-2'-hydroxyneamine + 2-oxoglutarate 2'-deamino-2'-hydroxy-6'-dehydroparomamine + L-glutamate
The reaction occurs in vivo in the opposite direction.
References
edit- ^ Park JW, Park SR, Nepal KK, Han AR, Ban YH, Yoo YJ, Kim EJ, Kim EM, Kim D, Sohng JK, Yoon YJ (October 2011). "Discovery of parallel pathways of kanamycin biosynthesis allows antibiotic manipulation". Nature Chemical Biology. 7 (11): 843–52. doi:10.1038/nchembio.671. PMID 21983602.
External links
edit- 2'-deamino-2'-hydroxyneamine+transaminase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
