2,4-Dichlorobenzyl alcohol is a mild antiseptic, able to kill bacteria and viruses associated with mouth and throat infections. It is a common ingredient in throat lozenges such as Cofsils, Strepsils, Lorsept, and Gorpils. It is also an ingredient in the European product Neo Borocillina.[1] A low-pH throat lozenge containing dichlorobenzyl alcohol (1.2 mg) and amylmetacresol (0.6 mg) has been found to deactivate respiratory syncytial virus and SARS-Cov, but not adenovirus or rhinovirus.[2] A dentifrice containing 10% sodium benzoate and 0.3% dichlorobenzyl alcohol maintains antimicrobial activity for 5 to 10 minutes after brushing.[3]
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| Names | |
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| Preferred IUPAC name
(2,4-Dichlorophenyl)methanol | |
| Other names
Dybenal
Rapidosept Myacide SP | |
| Identifiers | |
3D model (JSmol)
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| ChEBI | |
| ChEMBL | |
| ChemSpider | |
| ECHA InfoCard | 100.015.646 |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C7H6Cl2O | |
| Molar mass | 177.02 g·mol−1 |
| Melting point | 57 to 60 °C (135 to 140 °F; 330 to 333 K) |
| Boiling point | 150 °C (302 °F; 423 K) 25 mmHg |
| Pharmacology | |
| R02AA03 (WHO) | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ^ "Neo Borocillina". drugs.com. Archived from the original on 2020-09-13. Retrieved 2018-01-23.
- ^ Oxford JS, Lambkin R, Gibb I, Balasingam S, Chan C, Catchpole A (2005). "A throat lozenge containing amyl meta cresol and dichlorobenzyl alcohol has a direct virucidal effect on respiratory syncytial virus, influenza A and SARS-CoV". Antiviral Chemistry & Chemotherapy. 16 (2): 129–34. doi:10.1177/095632020501600205. PMID 15889535.
- ^ Ostergaard E (1994). "Evaluation of the antimicrobial effects of sodium benzoate and dichlorobenzyl alcohol against dental plaque microorganisms. An in vitro study". Acta Odontol Scand. 52 (6): 335–45. doi:10.3109/00016359409029031. PMID 7887143.