2,4-dienoyl-CoA reductase 1

2,4-dienoyl-CoA reductase 1 is a protein that in humans is encoded by the DECR1 gene.

DECR1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1W6U, 1W73, 1W8D
Identifiers
Aliases	DECR1, DECR, NADPH, SDR18C1, 2,4-dienoyl-CoA reductase 1, mitochondrial, 2,4-dienoyl-CoA reductase 1
External IDs	OMIM: 222745; MGI: 1914710; HomoloGene: 68178; GeneCards: DECR1; OMA:DECR1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.3 Start 90,001,405 bp End 90,053,633 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 A2 Start 15,917,240 bp End 15,945,507 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle right ventricle right adrenal gland right adrenal cortex right lobe of liver apex of heart left adrenal gland right auricle left adrenal cortex mucosa of transverse colon Top expressed in right ventricle myocardium of ventricle interventricular septum brown adipose tissue cardiac muscles cardiac muscle tissue of left ventricle left lobe of liver intercostal muscle tunica adventitia of aorta thoracic diaphragm More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity, acting on NAD(P)H oxidoreductase activity 2,4-dienoyl-CoA reductase (NADPH) activity NADPH binding Cellular component mitochondrial matrix extracellular exosome mitochondrion nucleus nucleoplasm cytosol Biological process fatty acid beta-oxidation protein homotetramerization fatty acid metabolic process lipid metabolism positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1666 67460 Ensembl ENSG00000104325 ENSMUSG00000028223 UniProt Q16698 Q9CQ62 RefSeq (mRNA) NM_001359 NM_001330575 NM_026172 RefSeq (protein) NP_001317504 NP_001350 NP_080448 Location (UCSC) Chr 8: 90 – 90.05 Mb Chr 4: 15.92 – 15.95 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Function

This gene encodes an accessory enzyme which participates in the beta-oxidation and metabolism of unsaturated fatty enoyl-CoA esters.

See also

• DECR2

Further reading

• Alphey MS, Yu W, Byres E, Li D, Hunter WN (2005). "Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site". J. Biol. Chem. 280 (4): 3068–77. doi:10.1074/jbc.M411069200. PMID 15531764.
• Yu W, Chu X, Chen G, Li D (2005). "Studies of human mitochondrial 2,4-dienoyl-CoA reductase". Arch. Biochem. Biophys. 434 (1): 195–200. doi:10.1016/j.abb.2004.10.018. PMID 15629123.
• Rosenzweig SD (2008). "Inflammatory manifestations in chronic granulomatous disease (CGD)". J. Clin. Immunol. 28 (Suppl 1): S67–72. doi:10.1007/s10875-007-9160-5. PMID 18193341. S2CID 5965278.
• Kardon T, Senesi S, Marcolongo P, Legeza B, Bánhegyi G, Mandl J, Fulceri R, Benedetti A (2008). "Maintenance of luminal NADPH in the endoplasmic reticulum promotes the survival of human neutrophil granulocytes". FEBS Lett. 582 (13): 1809–15. doi:10.1016/j.febslet.2008.04.045. PMID 18472006. S2CID 41166916.
• Mizuta I, Tsunoda T, Satake W, Nakabayashi Y, Watanabe M, Takeda A, Hasegawa K, Nakashima K, Yamamoto M, Hattori N, Murata M, Toda T (2008). "Calbindin 1, fibroblast growth factor 20, and alpha-synuclein in sporadic Parkinson's disease". Hum. Genet. 124 (1): 89–94. doi:10.1007/s00439-008-0525-5. PMID 18568448. S2CID 20604147.
• Moe KT, Woon FP, De Silva DA, Wong P, Koh TH, Kingwell B, Chin-Dusting J, Wong MC (2008). "Association of acute ischemic stroke with the MTHFR C677T polymorphism but not with NOS3 gene polymorphisms in a Singapore population". Eur. J. Neurol. 15 (12): 1309–14. doi:10.1111/j.1468-1331.2008.02308.x. PMID 19049547. S2CID 10457617.
• Hosgood HD, Zhang L, Shen M, Berndt SI, Vermeulen R, Li G, Yin S, Yeager M, Yuenger J, Rothman N, Chanock S, Smith M, Lan Q (2009). "Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity". Occup Environ Med. 66 (12): 848–53. doi:10.1136/oem.2008.044024. PMC 2928224. PMID 19773279.
• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
• Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9): e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.