2,8-Dihydroxyhexahydrochrysene

2,8-Dihydroxyhexahydrochrysene
Clinical data
ATC code	None;
Identifiers
PubChem CID	12519776;
ChemSpider	23351465;
Chemical and physical data
Formula	C18H18O2
Molar mass	266.340 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1C=CC2=C(C=1)CCC3C2CCC4C3=CC=C(O)C=4;
	InChI InChI=1S/C18H18O2/c19-13-3-7-15-11(9-13)1-5-17-16-8-4-14(20)10-12(16)2-6-18(15)17/h3-4,7-10,17-20H,1-2,5-6H2; Key:WKSBLYZBEPGLTB-UHFFFAOYSA-N;

2,8-Dihydroxyhexahydrochrysene (2,8-DHHHC) is a synthetic, nonsteroidal weak estrogen with approximately 1/2,000th the estrogenic potency of the structurally-related estrogen diethylstilbestrol.^[1]^[2]^[3] It is said to be intermediate in structure between estradiol and hexestrol, but conversely to both of them, it is drastically less potent in comparison.^[3]

References

^ Maximov PY, McDaniel RE, Jordan VC (23 July 2013). Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–. ISBN 978-3-0348-0664-0.
^ Jordan VC (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–. ISBN 978-0-299-10480-1.
^ ^a ^b Wilds AL, Sutton RE (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of Organic Chemistry. 16 (9): 1371–1379. doi:10.1021/jo50003a006. ISSN 0022-3263.

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[MaximovMcDaniel2013-1] Maximov PY, McDaniel RE, Jordan VC (23 July 2013). Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 4–. ISBN 978-3-0348-0664-0.

[Jordan1986-2] Jordan VC (1986). Estrogen/antiestrogen Action and Breast Cancer Therapy. Univ of Wisconsin Press. pp. 22–. ISBN 978-0-299-10480-1.

[WildsSutton1951-3] Wilds AL, Sutton RE (1951). "Cyclic Analogs of Hexestrol in the Chrysene Series". The Journal of Organic Chemistry. 16 (9): 1371–1379. doi:10.1021/jo50003a006. ISSN 0022-3263.

[1]

[2]

[3]

Clinical data

ATC code	None
Identifiers
PubChem CID	12519776
ChemSpider	23351465
Chemical and physical data
Formula	C₁₈H₁₈O₂
Molar mass	266.340 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES OC1C=CC2=C(C=1)CCC3C2CCC4C3=CC=C(O)C=4
InChI InChI=1S/C18H18O2/c19-13-3-7-15-11(9-13)1-5-17-16-8-4-14(20)10-12(16)2-6-18(15)17/h3-4,7-10,17-20H,1-2,5-6H2 Key:WKSBLYZBEPGLTB-UHFFFAOYSA-N

2,8-Dihydroxyhexahydrochrysene

See also

References