2-(R)-hydroxypropyl-CoM dehydrogenase

In enzymology, a 2-(R)-hydroxypropyl-CoM dehydrogenase (EC 1.1.1.268) is an enzyme that catalyzes the chemical reaction

2-(R)-hydroxypropyl-CoM dehydrogenase
Identifiers
EC no.	1.1.1.268
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

2-(R)-hydroxypropyl-CoM + NAD⁺ $\rightleftharpoons$ 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(R)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD⁺ oxidoreductase. This enzyme is also called 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2CFC.

References

• Allen JR, Clark DD, Krum JG, Ensign SA (1999). "A role for coenzyme M (2-mercaptoethanesulfonic acid) in a bacterial pathway of aliphatic epoxide carboxylation". Proc. Natl. Acad. Sci. U.S.A. 96 (15): 8432–7. Bibcode:1999PNAS...96.8432A. doi:10.1073/pnas.96.15.8432. PMC 17533. PMID 10411892.