2-(acetamidomethylene)succinate hydrolase

In enzymology, a 2-(acetamidomethylene)succinate hydrolase (EC 3.5.1.29) is an enzyme that catalyzes the chemical reaction

2-(acetamidomethylene)succinate hydrolase
Identifiers
EC no.3.5.1.29
CAS no.37289-09-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
2-(acetamidomethylene)succinate + 2 H2O acetate + succinate semialdehyde + NH3 + CO2

Thus, the two substrates of this enzyme are 2-(acetamidomethylene)succinate and H2O, whereas its 4 products are acetate, succinate semialdehyde, NH3, and CO2.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is 2-(acetamidomethylene)succinate amidohydrolase (deaminating, decarboxylating). This enzyme is also called alpha-(N-acetylaminomethylene)succinic acid hydrolase. This enzyme participates in vitamin B6 metabolism.

References

edit
  • Huynh MS, Snell EE (1985). "Enzymes of vitamin B6 degradation. Purification and properties of two N-acetylamidohydrolases". J. Biol. Chem. 260 (4): 2379–83. PMID 3972793.
  • Nyns EJ, Zach D, Snell EE (1969). "The bacterial oxidation of vitamin B6. 8. Enzymatic breakdown of alpha-(N-acetylaminomethylene) succinic acid". J. Biol. Chem. 244 (10): 2601–5. PMID 5769993.