2-Amino-3-carboxymuconic semialdehyde[1][2] is an intermediate in the metabolism of tryptophan in the tryptophan-niacin catabolic pathway. Quinolinate is a neurotoxin formed nonenzymatically from 2-amino-3-carboxymuconic semialdehyde in mammalian tissues. 2-Amino-3-carboxymuconic semialdehyde is enzymatically converted to 2-aminomuconate via 2-aminomuconic semialdehyde.
Names | |
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Preferred IUPAC name
(2Z)-2-Amino-3-[(1Z)-3-oxoprop-1-en-1-yl]but-2-enedioic acid | |
Identifiers | |
3D model (JSmol)
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ChEBI | |
ChemSpider | |
PubChem CID
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CompTox Dashboard (EPA)
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Properties | |
C7H7NO5 | |
Molar mass | 185.13 g/mol |
Density | 1.527 g/mL |
Boiling point | 389 °C (732 °F; 662 K) |
Hazards | |
Flash point | 189 °C (372 °F; 462 K) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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References
edit- ^ "UniProt". www.uniprot.org. Retrieved 2022-11-22.
- ^ "Human Metabolome Database: Showing metabocard for 2-Amino-3-carboxymuconic acid semialdehyde (HMDB0001330)". hmdb.ca. Retrieved 2022-11-22.