2-Amino-4-deoxychorismate dehydrogenase

2-Amino-4-deoxychorismate dehydrogenase (EC 1.3.99.24, ADIC dehydrogenase, 2-amino-2-deoxyisochorismate dehydrogenase, SgcG) is an enzyme with systematic name (2S)-2-amino-4-deoxychorismate:FMN oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

2-amino-4-deoxychorismate dehydrogenase
Identifiers
EC no.1.3.99.24
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins
(2S)-2-amino-4-deoxychorismate + FMN 3-(1-carboxyvinyloxy)anthranilate + FMNH2

This enzyme participates in the formation of the benzoxazolinate moiety of the enediyne antitumour antibiotic C-1027].

References

edit
  1. ^ Van Lanen SG, Lin S, Shen B (January 2008). "Biosynthesis of the enediyne antitumor antibiotic C-1027 involves a new branching point in chorismate metabolism". Proceedings of the National Academy of Sciences of the United States of America. 105 (2): 494–9. Bibcode:2008PNAS..105..494V. doi:10.1073/pnas.0708750105. PMC 2206564. PMID 18182490.
  2. ^ Yu L, Mah S, Otani T, Dedon P (1995). "The benzoxazolinate of C-1027 confers intercalative DNA binding". J. Am. Chem. Soc. 117 (34): 8877–8878. doi:10.1021/ja00139a032.
edit