2-deoxy-scyllo-inosamine dehydrogenase (EC 1.1.1.329, neoA (gene name), kanK (gene name)) is an enzyme with systematic name 2-deoxy-scyllo-inosamine:NAD(P)+ 1-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction
| 2-deoxy-scyllo-inosamine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.329 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2-deoxy-scyllo-inosamine + NAD(P)+ 3-amino-2,3-dideoxy-scyllo-inosose + NAD(P)H + H+
This enzyme requires zinc.
References
edit- ^ Kudo F, Yamamoto Y, Yokoyama K, Eguchi T, Kakinuma K (December 2005). "Biosynthesis of 2-deoxystreptamine by three crucial enzymes in Streptomyces fradiae NBRC 12773". The Journal of Antibiotics. 58 (12): 766–74. doi:10.1038/ja.2005.104. PMID 16506694.
- ^ Nepal KK, Oh TJ, Sohng JK (May 2009). "Heterologous production of paromamine in Streptomyces lividans TK24 using kanamycin biosynthetic genes from Streptomyces kanamyceticus ATCC12853". Molecules and Cells. 27 (5): 601–8. doi:10.1007/s10059-009-0080-5. PMID 19466609.
External links
edit- 2-deoxy-scyllo-inosamine+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
