2-acylglycerophosphocholine O-acyltransferase

In enzymology, a 2-acylglycerophosphocholine O-acyltransferase (EC 2.3.1.62) is an enzyme that catalyzes the chemical reaction

2-acylglycerophosphocholine O-acyltransferase
Identifiers
EC no.2.3.1.62
CAS no.64295-73-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
acyl-CoA + 2-acyl-sn-glycero-3-phosphocholine CoA + phosphatidylcholine

Thus, the two substrates of this enzyme are acyl-CoA and 2-acyl-sn-glycero-3-phosphocholine, whereas its two products are CoA and phosphatidylcholine.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:2-acyl-sn-glycero-3-phosphocholine O-acyltransferase. Other names in common use include 2-acylglycerol-3-phosphorylcholine acyltransferase, and 2-acylglycerophosphocholine acyltransferase. This enzyme participates in glycerophospholipid metabolism.

References

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  • Lands WE, Hart P (1965). "Metabolism of glycerolipids. VI. Specificities of acyl coenzyme A:phospholipid acyltransferases". J. Biol. Chem. 240: 1905–1911. PMID 14299609.
  • Van Den Bosch H, Van Golde MG, Slotboom AJ, Van Deenen LL (1968). "The acylation of isomeric monoacyl phosphatidylcholines". Biochim. Biophys. Acta. 152 (4): 694–703. doi:10.1016/0005-2760(68)90115-x. PMID 5660084.