2-alkyn-1-ol dehydrogenase

In enzymology, a 2-alkyn-1-ol dehydrogenase (EC 1.1.1.165) is an enzyme that catalyzes the chemical reaction below:

2-alkyn-1-ol dehydrogenase
Identifiers
EC no.1.1.1.165
CAS no.54576-94-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
2-butyne-1,4-diol + NAD+ 4-hydroxy-2-butynal + NADH + H+

The two substrates of this enzyme are 2-butyne-1,4-diol and NAD+, whereas its 3 products are 4-hydroxy-2-butynal, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-butyne-1,4-diol:NAD+ 1-oxidoreductase.[1]

References

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  1. ^ Miyoshi T, Sato H, Harada T (1974-08-26). "Purification and characterization of 2-alkyne-1-ol dehydrogenase induced by 2-butyne-1,4-diol in Fusarium merismoides B11". Biochimica et Biophysica Acta (BBA) - Enzymology. 358 (2): 231–239. doi:10.1016/0005-2744(74)90452-5. ISSN 0005-2744.