2-hydroxychromene-2-carboxylate isomerase (EC 5.99.1.4, HCCA isomerase, 2HC2CA isomerase, 2-hydroxychromene-2-carboxylic acid isomerase) is an enzyme with systematic name 2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| 2-hydroxychromene-2-carboxylate isomerase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.99.1.4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 2-hydroxy-2H-chromene-2-carboxylate (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate
This enzyme is involved in naphthalene degradation.
References
edit- ^ Ohmoto T, Kinoshita T, Moriyoshi K, Sakai K, Hamada N, Ohe T (September 1998). "Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2". Journal of Biochemistry. 124 (3): 591–7. doi:10.1093/oxfordjournals.jbchem.a022152. PMID 9722670.
- ^ Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J (July 2006). "Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6". Microbiology. 152 (Pt 7): 1929–40. doi:10.1099/mic.0.28783-0. PMID 16804169.
- ^ Eaton RW (December 1994). "Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid". Journal of Bacteriology. 176 (24): 7757–62. doi:10.1128/jb.176.24.7757-7762.1994. PMC 197239. PMID 8002605.
- ^ Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN (June 2007). "2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida". Biochemistry. 46 (23): 6710–22. doi:10.1021/bi700356u. PMID 17508726.
External links
edit- 2-hydroxychromene-2-carboxylate+isomerase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
