2-methylisoborneol synthase (EC 4.2.3.118, sco7700, 2-MIB cyclase, MIB synthase, MIBS) is an enzyme with systematic name (E)-2-methylgeranyl-diphosphate diphosphate-lyase (cyclizing, 2-methylisoborneol-forming).[1][2][3] This enzyme catalyses the following chemical reaction
| 2-methylisoborneol synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.2.3.118 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- (E)-2-methylgeranyl diphosphate + H2O 2-methylisoborneol + diphosphate
The product, 2-methylisoborneol, is a characteristic odiferous compound with a musty smell produced by soil microorganisms.
References
edit- ^ Wang CM, Cane DE (July 2008). "Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor". Journal of the American Chemical Society. 130 (28): 8908–9. doi:10.1021/ja803639g. PMC 3023297. PMID 18563898.
- ^ Komatsu M, Tsuda M, Omura S, Oikawa H, Ikeda H (May 2008). "Identification and functional analysis of genes controlling biosynthesis of 2-methylisoborneol". Proceedings of the National Academy of Sciences of the United States of America. 105 (21): 7422–7. Bibcode:2008PNAS..105.7422K. doi:10.1073/pnas.0802312105. PMC 2387273. PMID 18492804.
- ^ Giglio S, Chou WK, Ikeda H, Cane DE, Monis PT (February 2011). "Biosynthesis of 2-methylisoborneol in cyanobacteria". Environmental Science & Technology. 45 (3): 992–8. Bibcode:2011EnST...45..992G. doi:10.1021/es102992p. PMC 3699865. PMID 21174459.
External links
edit- 2-methylisoborneol+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
