20α-Dihydrotrengestone (20α-DHTG), also known as 20α-hydroxytrengestone, as well as 6-chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one, is a progestin and the major active metabolite of trengestone.[1][2] It appears that trengestone is a prodrug of 20α-DHTG, as it is largely transformed into this metabolite when given orally in humans.[2][1] 20α-DHTG has potent progestogenic activity similarly to trengestone.[1]
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| Clinical data | |
|---|---|
| Other names | 20α-DHTG; 20α-Hydroxytrengestone; 6-Chloro-20(S)-hydroxy-9β,10α-pregna-1,4,6-trien-3-one |
| Drug class | Progestin; Progestogen |
| Pharmacokinetic data | |
| Elimination half-life | 8–14 hours[1] |
| Chemical and physical data | |
| Formula | C21H26ClO2 |
| Molar mass | 345.89 g·mol−1 |
| 3D model (JSmol) | |
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See also
editReferences
edit- ^ a b c d Dixon R, Tormey P, Darragh A (March 1975). "Disposition of the retro-steroid progestogen, 6-chloro-9beta, 10alpha-pregna-1,4,6-triene-3,20-dione (Ro 4-8347), in man". Contraception. 11 (3): 339–46. doi:10.1016/0010-7824(75)90042-6. PMID 1116370.
- ^ a b Breuer H, Kime DE, Knuppen R (September 1973). "Metabolism of 6-chloro-9 beta, 10 alpha-pregna-1,4,6-triene-3,20-dione in rat, rabbit, monkey and man". Acta Endocrinol. 74 (1): 127–43. doi:10.1530/acta.0.0740127. PMID 4202495.
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