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The 2006 NASDAQ-100 Open was the 22nd edition of this tennis tournament and was played on outdoor hard courts. The tournament was part of the ATP Masters Series of the 2006 ATP Tour and was classified as a Tier I event on the 2006 WTA Tour. Both the men's and the women's events took place at the Tennis Center at Crandon Park in Key Biscayne, Florida, United States, from March 20 through April 2, 2006.
| 2006 NASDAQ-100 Open | |
|---|---|
| Date | March 20 – April 2 |
| Edition | 22nd |
| Category | ATP Masters Series (men) Tier I Series (women) |
| Surface | Hard / outdoor |
| Location | Key Biscayne, Florida, U.S. |
| Venue | Tennis Center at Crandon Park |
| Champions | |
| Men's singles | |
 Roger Federer | |
| Women's singles | |
 Svetlana Kuznetsova | |
| Men's doubles | |
 Jonas Björkman /  Max Mirnyi | |
| Women's doubles | |
 Lisa Raymond /  Samantha Stosur | |
Finals
editMen's singles
edit Roger Federer defeated 
Ivan Ljubičić 7–6(7–5), 7–6(7–4), 7–6(8–6)
Women's singles
edit Svetlana Kuznetsova defeated Maria Sharapova 6–4, 6–3
Men's doubles
edit Jonas Björkman & Max Mirnyi defeated Bob Bryan & Mike Bryan 6–4, 6–4
Women's doubles
edit Lisa Raymond & Samantha Stosur defeated 
Liezel Huber & Martina Navratilova 6–4, 7–5