The 2006 NASDAQ-100 Open was the 22nd edition of this tennis tournament and was played on outdoor hard courts. The tournament was part of the ATP Masters Series of the 2006 ATP Tour and was classified as a Tier I event on the 2006 WTA Tour. Both the men's and the women's events took place at the Tennis Center at Crandon Park in Key Biscayne, Florida, United States, from March 20 through April 2, 2006.

2006 NASDAQ-100 Open
DateMarch 20 – April 2
Edition22nd
CategoryATP Masters Series (men)
Tier I Series (women)
SurfaceHard / outdoor
LocationKey Biscayne, Florida, U.S.
VenueTennis Center at Crandon Park
Champions
Men's singles
Switzerland Roger Federer
Women's singles
Russia Svetlana Kuznetsova
Men's doubles
Sweden Jonas Björkman / Belarus Max Mirnyi
Women's doubles
United States Lisa Raymond / Australia Samantha Stosur
← 2005 · Miami Open · 2007 →

Finals

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Men's singles

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  Roger Federer defeated   Ivan Ljubičić 7–6(7–5), 7–6(7–4), 7–6(8–6)

Women's singles

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  Svetlana Kuznetsova defeated   Maria Sharapova 6–4, 6–3

Men's doubles

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  Jonas Björkman &   Max Mirnyi defeated   Bob Bryan &   Mike Bryan 6–4, 6–4

Women's doubles

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  Lisa Raymond &   Samantha Stosur defeated   Liezel Huber &   Martina Navratilova 6–4, 7–5

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