Four-time defending champion Esther Vergeer and her partner Sharon Walraven defeated Daniela Di Toro and Aniek van Koot in the final, 6–3, 6–3 to win the women's doubles wheelchair tennis title at the 2010 US Open.
| Wheelchair women's doubles | |
|---|---|
| 2010 US Open | |
| Champions |  Esther Vergeer Sharon Walraven |
| Runners-up |  Daniela Di Toro Aniek van Koot |
| Score | 6–3, 6–3 |
Korie Homan and Vergeer were the reigning champions, but Homan did not participate.
Seeds
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Daniela Di Toro / 
Aniek van Koot (final)- Esther Vergeer / Sharon Walraven (champions)
Doubles
editKey
edit- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
edit| Semifinals | Finals | ||||||||||||
| 1 | Daniela Di Toro Aniek van Koot
| 6 | 6 | ||||||||||
 Annick Sevenans Mackenzie Soldan
| 2 | 3 | |||||||||||
| 1 | Daniela Di Toro Aniek van Koot
| 3 | 3 | ||||||||||
| 2 | Esther Vergeer Sharon Walraven
| 6 | 6 | ||||||||||
 Florence Alix-Gravellier Jiske Griffioen
| 4 | 4 | |||||||||||
| 2 | Esther Vergeer Sharon Walraven
| 6 | 6 | ||||||||||