The quarterfinals were two-legged ties determined on aggregate score. The first legs were played on March 20. The return legs were played on March 27. The group winners in each tie, listed as "Team #1", hosted the second leg.
| Team #1 | Agg. | Team #2 | 1st leg | 2nd leg |
|---|---|---|---|---|
Valencia Basket  |
156–138 |  Budućnost Voli |
71–75 | 85–63 |
Donetsk  |
145–154 |  Lietuvos Rytas |
65–76 | 80–78 |
Spartak St. Petersburg  |
154–135 |  ČEZ Nymburk |
68–64 | 86–71 |
| Lokomotiv-Kuban |
153–158 | Khimki |
72–81 | 81–77 |
All times are CET (UTC+1).
Game 1
edit19 March 2012
19:00 |
| ČEZ Nymburk |
64–68 | Spartak St. Petersburg |
| Scoring by quarter: 21–17, 18–26, 9–16, 16–9 | ||
| Pts: Simmons 23 Rebs: Wilson 6 Asts: Lawrence, Simmons 3 |
Pts: Beverley 19 Rebs: Keyru 6 Asts: Strēlnieks 4 | |
20 March 2012
16:00 |
| Khimki |
81–72 | Lokomotiv-Kuban |
| Scoring by quarter: 18–21, 22–21, 19–18, 22–12 | ||
| Pts: Kelati 20 Rebs: Monia 7 Asts: Quinn 5 |
Pts: Massey, Rivers 14 Rebs: Traore 8 Asts: Ilievski 5 | |
Basketball Center of Moscow Region, Khimki
Attendance: 2,850 Referees: Christos Christodoulou (GRE), Sinisa Herceg (CRO), Petri Mantyla (FIN) |
20 March 2012
18:00 |
| Lietuvos Rytas |
76–65 | Donetsk |
| Scoring by quarter: 18–9, 23–22, 20–18, 15–16 | ||
| Pts: Babrauskas 15 Rebs: Valančiūnas 10 Asts: Rice 7 |
Pts: Radenović 16 Rebs: Radenović 10 Asts: Avdalović 4 | |
Siemens Arena, Vilnius
Attendance: 9,200 Referees: Recep Ankarali (TUR), Milivoje Jovcic (SRB), Damir Javor (SLO) |
20 March 2012
18:30 |
| Budućnost Voli |
75–71 | Valencia Basket |
| Scoring by quarter: 20–21, 20–18, 14–22, 21–10 | ||
| Pts: Dubljević 15 Rebs: Dubljević 8 Asts: A. Popović, Anderson 3 |
Pts: de Colo 12 Rebs: Claver 7 Asts: Marković 7 | |
Morača Sports Center, Podgorica
Attendance: 3,100 Referees: Guerrino Cerebuch (ITA), Elias Koromilas (GRE), Tomas Trawicki (POL) |
Game 2
edit27 March 2012
17:00 |
| Spartak St. Petersburg |
86–71 | ČEZ Nymburk |
| Scoring by quarter: 21–18, 23–21, 26–17, 16–15 | ||
| Pts: Strēlnieks, Halperin 19 Rebs: Beverley 7 Asts: Halperin 7 |
Pts: Simmons 22 Rebs: Pumprla, Simmons 7 Asts: Lawrence 7 | |
Yubileyny Sports Palace, Saint Petersburg
Attendance: 2,700 Referees: Sreten Radovic (CRO), Roberto Chiari (ITA), Radomir Vojinovic (MNE) |
27 March 2012
17:00 |
| Lokomotiv-Kuban |
81–77 | Khimki |
| Scoring by quarter: 22–24, 11–22, 26–16, 22–15 | ||
| Pts: Traore 22 Rebs: Massey 8 Asts: Rivers 2 |
Pts: Fridzon 17 Rebs: Fridzon 7 Asts: Quinn 5 | |
Olympus Arena, Krasnodar
Attendance: 4,000 Referees: Daniel Hierrezuelo (ESP), Spiros Gkontas (GRE), Rustu Nuran (TUR) |
27 March 2012
18:00 |
| Donetsk |
80–78 | Lietuvos Rytas |
| Scoring by quarter: 17–28, 17–13, 13–13, 33–24 | ||
| Pts: Curry 26 Rebs: Radenović 8 Asts: Avdalović, Radenović 4 |
Pts: Rice 14 Rebs: Valančiūnas 7 Asts: Rice 5 | |
Druzhba Palace of Sports, Donetsk
Attendance: 4,000 Referees: Vicente Bulto (ESP), Antonio Conde (ESP), Zdravko Rutesic (MNE) |
27 March 2012
20:30 |
| Valencia Basket |
85–63 | Budućnost Voli |
| Scoring by quarter: 28–11, 16–17, 28–14, 13–21 | ||
| Pts: Claver 13 Rebs: Caner-Medley 8 Asts: de Colo 5 |
Pts: Dubljević 17 Rebs: Vitkovac 6 Asts: Anderson 5 | |
Pabellon Municipal Fuente San Luis, Valencia
Attendance: 8,800 Referees: Luis Lopes (POR), Boris Shulga (UKR), Panagiotis Anastopoulos (GRE) |