2022–2023 United Kingdom group A streptococcus outbreak
In late 2022, an ongoing disease outbreak caused by the bacterium Streptococcus pyogenes, a Lancefield group A streptococcus, began in the United Kingdom. It is often referred to as the Strep A outbreak in the media. These bacteria cause group A streptococcal infections (Strep A or iGAS) and scarlet fever.[1][2] In the UK, 516 deaths from iGAS have been recorded, of which 61 were children, 52 in England,[3] five in Wales,[4] three in Scotland,[5] and one in Northern Ireland.[6]
| 2022–2023 United Kingdom Lancefield group A streptococcus outbreak | |
|---|---|
 The tongue of a child showing the signs of scarlet fever caused by Lancefield group A streptococci | |
| Disease | Group A streptococcal infection (iGAS) Scarlet fever |
| Bacteria strain | Group A streptococcus |
| Location | United Kingdom |
| Date | 12 September 2022 |
| Confirmed cases | iGAS: 3,729 Scarlet fever: 58,972 |
Deaths | 516 |
| Fatality rate | 13.7% (iGAS) |
There were 3,729 notifications of iGAS recorded in England between 12 September 2022 and 18 June 2023. Notifications of scarlet fever have also seen a large increase, with 58,972 infections reported in England during the same period. The UKHSA said that rate of iGAS cases were fluctuating at the upper end of the range expected for the time of year after the high levels seen during December 2022.[3]
Background
editGroup A streptococcal infections are diseases, including scarlet fever, which are caused by the bacterium Streptococcus pyogenes, a Lancefield group A streptococcus (GAS).[1] In 2007 it was estimated that GAS infections cause over 500,000 deaths per year.[7] On very rare occasions, GAS enter the bloodstream and cause an illness called invasive group A strep (iGAS) which is very serious, particularly in older, younger and more vulnerable groups.[8]
In the United Kingdom, the UK Health Security Agency (UKHSA) has said that the last comparably high season was the 2017/18 season, where 355 deaths occurred from iGAS, 27 of which were children.[8] During this season the UKHSA also received total of 30,768 reports of scarlet fever.[3]
Deaths
editSo far, 516 deaths have been recorded within 7 days of an iGAS infection, 61 of which were children. The other reported deaths are people over the age of at least 15.[3] Usually, only one or two children under the age of 10 die from GAS infections during a typical winter.[5]
The case fatality rate (CFR) for iGAS from 12 September to 18 June in England was 13.7%.[3]
| Country | Child deaths | Adult deaths | Total |
|---|---|---|---|
 England
|
52 | 439 | 491 |
 Scotland
|
3 | 16 | 19[5] |
 Wales
|
5 | - | 5 |
| Northern Ireland | 1 | - | 1 |
 Total
|
61 | 455 | 516 |
| As of 18 June 2023[update] | |||
Cases
editThe UK Health Security Agency (UKHSA) said that an average of 2,861 (range 479 to 5,051) of scarlet fever were recorded during the same period over the past 5 years.[3]
The following table shows the number of notifications of iGAS and scarlet fever published by data from the UKHSA from 12 September to 18 June.[3]
| Country | iGAS | Scarlet fever | Total |
|---|---|---|---|
| England
|
3,729 | 58,972 | 62,701 |
| Scotland
|
- | - | - |
| Wales
|
- | - | - |
| Northern Ireland | - | - | - |
| Total
|
3,729 | 58,972 | 62,701 |
| As of 18 June 2023[update] | |||
Response
editDuring a House of Commons debate on 7 December 2022, Prime Minister Rishi Sunak was accused of downplaying the outbreak after leader of the opposition Keir Starmer questioned him on his handling of the disease. Sunak stated that the infection 'has not become more lethal'.[9]
A survey of 626 parents' attitudes towards Strep A revealed a range of misinformation narratives, with 32% thinking that COVID-19 vaccines and flu vaccines were partly responsible for an increase in Strep A infections. Furthermore, 49% were unsure as to whether there is a link between nasal flu vaccines and Strep A. It also found that 28% were sceptical about Strep A, believing that it is a disguise being used to cover up something else. Increasing migration and refugee numbers were blamed by 33% of respondents for the increase in infections.[10]
References
edit- ^ a b Anjos LM, Marcondes MB, Lima MF, Mondelli AL, Okoshi MP (July 2014). "Streptococcal acute pharyngitis". Revista da Sociedade Brasileira de Medicina Tropical. 47 (4): 409–13. doi:10.1590/0037-8682-0265-2013. hdl:11449/114468. PMID 25229278.
- ^ "Managing scarlet fever". Drug and Therapeutics Bulletin. 55 (9): 102.2–102. September 2017. doi:10.1136/dtb.2017.8.0529. PMID 28882851. S2CID 25035714.
- ^ a b c d e f g "Group A streptococcal infections: 15th update on seasonal activity in England". UKHSA. 29 June 2023. Retrieved 15 July 2023.
- ^ "Weekly iGAS update". Public Health Wales. 3 January 2023. Retrieved 5 January 2023.
- ^ a b c "Group A streptococcal infections". Public Health Scotland. 25 January 2023. Retrieved 26 January 2023.
- ^ Mundasad, Smitha (8 December 2022). "GPs say parents need clearer strep A advice". BBC News. Retrieved 8 December 2022.
- ^ Cohen-Poradosu, Ronit; Kasper, Dennis (2007). "Group A Streptococcus Epidemiology and Vaccine Implications". Clinical Infectious Diseases. 45 (7): 863–5. doi:10.1086/521263. PMID 17806050.
- ^ a b "UKHSA update on scarlet fever and invasive Group A strep". UKHSA. 8 December 2022. Retrieved 9 December 2022.
- ^ Ashton, Emily (7 December 2022). "Strep A Infection Has Not Become 'More Lethal,' UK's Sunak Says". Bloomberg News. Retrieved 5 January 2023.
- ^ Barrett, Evie (16 December 2022). "Strep A misinformation on the rise as parents believe vaccines cause infections". PRWeek. Retrieved 14 January 2023.