- January 4 – Julio Ferrer, 68, Olympic sprinter (1976)[7]
- January 18 – Tito Matos, 53, requinto player[8]
- January 26 – Juan Báez, 86, Olympic basketball player (1960, 1964)[9]
- February 3 – Dean Zayas, 83, actor, director, and playwright[10]
- February 9 –
- April 16 – Mariano Ortiz, 77, Olympic basketball player (1968, 1972, 1976)[13]
- May 13 – Carlos Ortiz, 85, Hall of Fame boxer, world super lightweight (1959–1960) and WBA/WBC lightweight champion (1962–1965, 1965–1968)[14]
- July 1 – Joe Hatton, 74, Olympic basketball player (1968, 1972)[15]
- July 5 – José Vicente, 100, Olympic pole vaulter (1948, 1952)[16]
- July 17 – Héctor Tricoche, 66, salsa singer-songwriter[17]
- August 18 – Milt Ramírez, 72, baseball player (St. Louis Cardinals, Oakland Athletics)[18]
- ^ "Judge signs plan, resolves Puerto Rico bankruptcy battle". AP NEWS. 2022-01-18. Retrieved 2022-09-24.
- ^ "Puerto Rico formally exits bankruptcy following largest public debt restructuring". www.nbcnews.com. Associated Press. 17 March 2022. Retrieved 2022-09-24.
- ^ "11 dead, 31 rescued after boat capsizes near Puerto Rico". AP NEWS. 2022-05-12. Retrieved 2022-09-24.
- ^ "5 shot to death at public housing complex in Puerto Rico". AP NEWS. 2022-05-23. Retrieved 2022-09-24.
- ^ "The Bahamas confirms first case of monkeypox | Loop Caribbean News". Loop News. Retrieved 2022-09-24.
- ^ "Hurricane Fiona rips through powerless Puerto Rico". AP NEWS. 2022-09-18. Retrieved 2022-09-24.
- ^ "Olympedia – Julio Ferrer". www.olympedia.org. Retrieved 2022-09-24.
- ^ "Héctor "Tito" Matos, a master and custodian of Puerto Rican plena, has died at 53". WBGO. 2022-01-20. Retrieved 2022-09-24.
- ^ "Muere Johnny Báez, exjugador puertorriqueño del Real Madrid". MARCA (in Spanish). 2022-01-26. Retrieved 2022-09-24.
- ^ "Muere Dean Zayas, reconocido actor y director de teatro de Puerto Rico". El Nuevo Día (in Spanish). 2022-02-03. Retrieved 2022-09-24.
- ^ "Fallece la actriz y animadora Luz Odilea Font". El Nuevo Día (in Spanish). 2022-02-09. Retrieved 2022-09-24.
- ^ "Fallece Juan R. Melecio, expresidente de la CEE". Primera Hora (in Spanish). 2022-02-09. Retrieved 2022-09-24.
- ^ "Olympedia – Mariano Ortiz". www.olympedia.org. Retrieved 2022-09-24.
- ^ "Fallece Carlos Ortiz, considerado uno de los mejores boxeadores boricuas de la historia". Primera Hora (in Spanish). 2022-06-13. Retrieved 2022-09-24.
- ^ "Olympedia – Joe Hatton". www.olympedia.org. Retrieved 2022-09-24.
- ^ "Olympedia – José Vicente". www.olympedia.org. Retrieved 2022-09-24.
- ^ PR • •, Por TELEMUNDO (18 July 2022). "Fallece el cantante de salsa, Héctor Tricoche". Telemundo Puerto Rico (in Spanish). Retrieved 2022-09-24.
- ^ NotiCel. "Fallece el expelotero Milton Ramírez". www.noticel.com. Retrieved 2022-09-24.