23S rRNA (adenine1618-N6)-methyltransferase (EC 2.1.1.181, rRNA large subunit methyltransferase F, YbiN protein, rlmF (gene), m6A1618 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (adenine1618-N6)-methyltransferase.[1] This enzyme catalyses the following chemical reaction
| 23S rRNA (adenine1618-N6)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.181 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + adenine1618 in 23S rRNA S-adenosyl-L-homocysteine + N6-methyladenine1618 in 23S rRNA
The recombinant YbiN protein is able to methylate partially deproteinized 50 S ribosomal subunit.
References
edit- ^ Sergiev PV, Serebryakova MV, Bogdanov AA, Dontsova OA (January 2008). "The ybiN gene of Escherichia coli encodes adenine-N6 methyltransferase specific for modification of A1618 of 23 S ribosomal RNA, a methylated residue located close to the ribosomal exit tunnel". Journal of Molecular Biology. 375 (1): 291–300. doi:10.1016/j.jmb.2007.10.051. PMID 18021804.
External links
edit- 23S+rRNA+(adenine1618-N6)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
