23S rRNA (guanosine2251-2'-O)-methyltransferase (EC 2.1.1.185, rlmB (gene), yifH (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (guanosine2251-2'-O-)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| 23S rRNA (guanosine2251-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.185 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + guanosine2251 in 23S rRNA S-adenosyl-L-homocysteine + 2'-O-methylguanosine2251 in 23S rRNA
The enzyme catalyses the methylation of guanosine2251.
References
edit- ^ Lövgren JM, Wikström PM (December 2001). "The rlmB gene is essential for formation of Gm2251 in 23S rRNA but not for ribosome maturation in Escherichia coli". Journal of Bacteriology. 183 (23): 6957–60. doi:10.1128/jb.183.23.6957-6960.2001. PMC 95539. PMID 11698387.
- ^ Michel G, Sauvé V, Larocque R, Li Y, Matte A, Cygler M (October 2002). "The structure of the RlmB 23S rRNA methyltransferase reveals a new methyltransferase fold with a unique knot". Structure. 10 (10): 1303–15. doi:10.1016/s0969-2126(02)00852-3. PMID 12377117.
External links
edit- 23S+rRNA+(guanosine2251-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
