23S rRNA pseudouridine1911/1915/1917 synthase (also known as RluD)(EC 5.4.99.23, RluD, pseudouridine synthase RluD) is an enzyme with systematic name 23S rRNA-uridine1911/1915/1917 uracil mutase.[1][2][3][4] This enzyme catalyses the following chemical reaction
| 23S rRNA pseudouridine1911/1915/1917 synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 5.4.99.23 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- 23S rRNA uridine1911/uridine1915/uridine1917 23S rRNA pseudouridine1911/pseudouridine1915/pseudouridine1917
These nucleotides are located in the functionally important helix-loop 69 of 23S rRNA.
References
edit- ^ Leppik M, Peil L, Kipper K, Liiv A, Remme J (November 2007). "Substrate specificity of the pseudouridine synthase RluD in Escherichia coli". The FEBS Journal. 274 (21): 5759–66. doi:10.1111/j.1742-4658.2007.06101.x. PMID 17937767.
- ^ Ejby M, Sørensen MA, Pedersen S (December 2007). "Pseudouridylation of helix 69 of 23S rRNA is necessary for an effective translation termination". Proceedings of the National Academy of Sciences of the United States of America. 104 (49): 19410–5. Bibcode:2007PNAS..10419410E. doi:10.1073/pnas.0706558104. PMC 2148303. PMID 18032607.
- ^ Sivaraman J, Iannuzzi P, Cygler M, Matte A (January 2004). "Crystal structure of the RluD pseudouridine synthase catalytic module, an enzyme that modifies 23S rRNA and is essential for normal cell growth of Escherichia coli". Journal of Molecular Biology. 335 (1): 87–101. doi:10.1016/j.jmb.2003.10.003. PMID 14659742.
- ^ Wrzesinski J, Bakin A, Ofengand J, Lane BG (July 2000). "Isolation and properties of Escherichia coli 23S-RNA pseudouridine 1911, 1915, 1917 synthase (RluD)". IUBMB Life. 50 (1): 33–7. doi:10.1080/15216540050176566. PMID 11087118.
External links
edit- 23S+rRNA+pseudouridine1911/1915/1917+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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