27S pre-rRNA (guanosine2922-2'-O)-methyltransferase (EC 2.1.1.167, Spb1p (gene), YCL054W (gene)) is an enzyme with systematic name S-adenosyl-L-methionine:27S pre-rRNA (guanosine2922-2'-O-)-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
| 27S pre-rRNA (guanosine2922-2'-O)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.167 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- S-adenosyl-L-methionine + guanosine2922 in 27S pre-rRNA S-adenosyl-L-homocysteine + 2'-O-methylguanosine2922 in 27S pre-rRNA
Spb1p is a site-specific 2'-O-ribose RNA methyltransferase that catalyses the formation of 2'-O-methylguanosine2922.
References
edit- ^ Lapeyre B, Purushothaman SK (November 2004). "Spb1p-directed formation of Gm2922 in the ribosome catalytic center occurs at a late processing stage". Molecular Cell. 16 (4): 663–9. doi:10.1016/j.molcel.2004.10.022. PMID 15546625.
- ^ Bonnerot C, Pintard L, Lutfalla G (November 2003). "Functional redundancy of Spb1p and a snR52-dependent mechanism for the 2'-O-ribose methylation of a conserved rRNA position in yeast". Molecular Cell. 12 (5): 1309–15. doi:10.1016/S1097-2765(03)00435-0. PMID 14636587.
External links
edit- 27S+pre-rRNA+(guanosine2922-2'-O)-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
