3-Hydroxypicolinic acid

3-Hydroxy picolinic acid is a picolinic acid derivative and is a member of the pyridine family. It is used as a matrix for nucleotides in MALDI mass spectrometry analyses[1] and the synthesis of favipiravir.

3-Hydroxypicolinic acid
Skeletal formula of 3-hydroxypicolinic acid
Ball-and-stick model of the 3-hydroxypicolinic acid molecule
Names
Preferred IUPAC name
3-Hydroxypyridine-2-carboxylic acid
Other names
3-Hydroxypicolinic acid
3-Hydroxy-2-pyridinecarboxylic acid
Identifiers
3D model (JSmol)
ChEBI
ChemSpider
ECHA InfoCard 100.011.690 Edit this at Wikidata
UNII
  • InChI=1S/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10) checkY
    Key: BRARRAHGNDUELT-UHFFFAOYSA-N checkY
  • InChI=1/C6H5NO3/c8-4-2-1-3-7-5(4)6(9)10/h1-3,8H,(H,9,10)
    Key: BRARRAHGNDUELT-UHFFFAOYAC
  • C1=CC(=C(N=C1)C(=O)O)O
  • c1cc(c(nc1)C(=O)O)O
Properties
C6H5NO3
Molar mass 139.109
Appearance Light yellow needles
Melting point 208 to 212 °C (406 to 414 °F; 481 to 485 K)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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See also

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References

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  1. ^ Wu KJ, Steding A, Becker CH (1993). "Matrix-assisted laser desorption time-of-flight mass spectrometry of oligonucleotides using 3-hydroxypicolinic acid as an ultraviolet-sensitive matrix". Rapid Commun. Mass Spectrom. 7 (2): 142–6. Bibcode:1993RCMS....7..142W. doi:10.1002/rcm.1290070206. PMID 8457722.