3-carboxyethylcatechol 2,3-dioxygenase

In enzymology, a 3-carboxyethylcatechol 2,3-dioxygenase (EC 1.13.11.16) is an enzyme that catalyzes the chemical reaction

3-carboxyethylcatechol 2,3-dioxygenase
Identifiers
EC no.1.13.11.16
CAS no.105503-63-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins
3-(2,3-dihydroxyphenyl)propanoate + O2 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate

Thus, the two substrates of this enzyme are 3-(2,3-dihydroxyphenyl)propanoate and O2, whereas its product is 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate.

This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. The systematic name of this enzyme class is 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase (decyclizing). Other names in common use include 2,3-dihydroxy-beta-phenylpropionic dioxygenase, 2,3-dihydroxy-beta-phenylpropionate oxygenase, and 3-(2,3-dihydroxyphenyl)propanoate:oxygen 1,2-oxidoreductase. This enzyme participates in phenylalanine metabolism. It employs one cofactor, iron.

References

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  • Dagley S, Chapman PJ, Gibson DT (December 1965). "The metabolism of beta-phenylpropionic acid by an Achromobacter". The Biochemical Journal. 97 (3): 643–50. doi:10.1042/bj0970643. PMC 1264740. PMID 5881653.