3alpha-hydroxycholanate dehydrogenase

In enzymology, a 3alpha-hydroxycholanate dehydrogenase (EC 1.1.1.52) is an enzyme that catalyzes the chemical reaction

3-alpha-hydroxycholanate dehydrogenase
Identifiers
EC no.1.1.1.52
CAS no.9028-57-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
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NCBIproteins
3alpha-hydroxy-5beta-cholanate + NAD+ 3-oxo-5beta-cholanate + NADH + H+

Thus, the two substrates of this enzyme are 3alpha-hydroxy-5beta-cholanate and NAD+, whereas its 3 products are 3-oxo-5beta-cholanate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxy-5beta-cholanate:NAD+ oxidoreductase. This enzyme is also called alpha-hydroxy-cholanate dehydrogenase.

Structural studies

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As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1IHI.

References

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  • Hayaishi O, Sato Y, Jakoby WB, Stohlman EF (1955). "Reversible enzymatic oxidation of bile acids". Arch. Biochem. 56 (2): 554–5. doi:10.1016/0003-9861(55)90278-2. PMID 14377608.