4-hydroxybenzoate geranyltransferase (EC 2.5.1.93, PGT1, PGT2, 4HB geranyltransferase, 4HB:geranyltransferase, p-hydroxybenzoate geranyltransferase, PHB geranyltransferase, geranyl diphosphate:4-hydroxybenzoate geranyltransferase) is an enzyme with systematic name geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
| 4-hydroxybenzoate geranyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.93 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
- geranyl diphosphate + 4-hydroxybenzoate 3-geranyl-4-hydroxybenzoate + diphosphate
The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg2+.
References
edit- ^ Ohara K, Muroya A, Fukushima N, Yazaki K (June 2009). "Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid". The Biochemical Journal. 421 (2): 231–41. doi:10.1042/bj20081968. PMID 19392660.
- ^ Mühlenweg A, Melzer M, Li SM, Heide L (July 1998). "4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase". Planta. 205 (3): 407–13. doi:10.1007/s004250050337. PMID 9640665.
- ^ Yazaki K, Kunihisa M, Fujisaki T, Sato F (February 2002). "Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis". The Journal of Biological Chemistry. 277 (8): 6240–6. doi:10.1074/jbc.m106387200. PMID 11744717.
External links
edit- 4-hydroxybenzoate+geranyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
