4-Hydroxycyclohexanecarboxylate dehydrogenase

In enzymology, a 4-hydroxycyclohexanecarboxylate dehydrogenase (EC 1.1.1.226) is an enzyme that catalyzes the chemical reaction

4-hydroxycyclohexanecarboxylate dehydrogenase
Identifiers
EC no.1.1.1.226
CAS no.67272-36-0
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
trans-4-hydroxycyclohexanecarboxylate + NAD+ 4-oxocyclohexanecarboxylate + NADH + H+

Thus, the two substrates of this enzyme are trans-4-hydroxycyclohexanecarboxylate and NAD+, whereas its 3 products are 4-oxocyclohexanecarboxylate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is trans-4-hydroxycyclohexanecarboxylate:NAD+ 4-oxidoreductase. This enzyme is also called trans-4-hydroxycyclohexanecarboxylate dehydrogenase.

References

edit
  • Obata H, Uebayasi M, Kaneda T (1988). "Purification and properties of 4-hydroxycyclohexanecarboxylate dehydrogenase from Corynebacterium cyclohexanicum". Eur. J. Biochem. 174 (3): 451–8. doi:10.1111/j.1432-1033.1988.tb14119.x. PMID 3292236.