In enzymology, a 4-hydroxymandelate oxidase (EC 1.1.3.19) is an enzyme that catalyzes the chemical reaction
| 4-hydroxymandelate oxidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.3.19 | ||||||||
| CAS no. | 60976-30-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
- (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate + O2 4-hydroxybenzaldehyde + CO2 + H2O2
Thus, the two substrates of this enzyme are (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate and O2, whereas its 3 products are 4-hydroxybenzaldehyde, CO2, and H2O2.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with oxygen as acceptor. The systematic name of this enzyme class is (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate:oxygen 1-oxidoreductase. This enzyme is also called L-4-hydroxymandelate oxidase (decarboxylating). It has 2 cofactors: FAD, and Manganese.
References
edit- Bhat SG, Vaidyanathan CS (1976). "Purification and properties of L-4-hydroxymandelate oxidase from Pseudomonas convexa". Eur. J. Biochem. 68 (2): 323–31. doi:10.1111/j.1432-1033.1976.tb10818.x. PMID 976259.
