40S ribosomal protein S11

40S ribosomal protein S11 is a protein that in humans is encoded by the RPS11 gene.

RPS11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4UG0, 4V6X, 5A2Q, 5AJ0, 4KZY, 3J7R, 4D61, 4KZX, 4D5L, 4V5Z, 5FLX, 4UJD, 3J7P, 4KZZ, 4UJE, 4UJC
Identifiers
Aliases	RPS11, S11, ribosomal protein S11
External IDs	OMIM: 180471; MGI: 1351329; HomoloGene: 88443; GeneCards: RPS11; OMA:RPS11 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.33 Start 49,496,365 bp End 49,499,708 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 B3 Start 44,771,803 bp End 44,773,863 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh ganglionic eminence skin of hip skin of arm urethra human penis mucosa of sigmoid colon beta cell superficial temporal artery nipple Top expressed in epiblast embryo ventricular zone embryo ganglionic eminence blastocyst thymus morula zone of skin ileum More reference expression data BioGPS n/a
Gene ontology Molecular function rRNA binding structural constituent of ribosome protein binding RNA binding Cellular component cytoplasm cytosol ribosome focal adhesion intracellular anatomical structure nucleolus extracellular exosome nucleoplasm extracellular matrix membrane cytosolic small ribosomal subunit Biological process viral transcription SRP-dependent cotranslational protein targeting to membrane translational initiation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay protein biosynthesis rRNA processing osteoblast differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6205 27207 Ensembl ENSG00000142534 ENSMUSG00000003429 UniProt P62280 P62281 RefSeq (mRNA) NM_001015 NM_013725 RefSeq (protein) NP_001006 NP_038753 Location (UCSC) Chr 19: 49.5 – 49.5 Mb Chr 7: 44.77 – 44.77 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17P family of ribosomal proteins. It is located in the cytoplasm. The gene product of the E. coli ortholog (ribosomal protein S17) is thought to be involved in the recognition of termination codons. This gene is co-transcribed with a small nucleolar RNA gene, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

Further reading

• Wool IG, Chan YL, Glück A (1996). "Structure and evolution of mammalian ribosomal proteins". Biochem. Cell Biol. 73 (11–12): 933–47. doi:10.1139/o95-101. PMID 8722009.
• Ferrari S, Manfredini R, Tagliafico E, et al. (1990). "Noncoordinated expression of S6, S11, and S14 ribosomal protein genes in leukemic blast cells". Cancer Res. 50 (18): 5825–8. PMID 1697501.
• Lott JB, Mackie GA (1988). "Sequence of a cloned cDNA encoding human ribosomal protein S11". Nucleic Acids Res. 16 (3): 1205. doi:10.1093/nar/16.3.1205. PMC 334755. PMID 3267208.
• Vladimirov SN, Ivanov AV, Karpova GG, et al. (1996). "Characterization of the human small-ribosomal-subunit proteins by N-terminal and internal sequencing, and mass spectrometry". Eur. J. Biochem. 239 (1): 144–9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699.
• Higa S, Yoshihama M, Tanaka T, Kenmochi N (2000). "Gene organization and sequence of the region containing the ribosomal protein genes RPL13A and RPS11 in the human genome and conserved features in the mouse genome". Gene. 240 (2): 371–7. doi:10.1016/S0378-1119(99)00429-1. PMID 10580157. S2CID 25643638.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

• Overview of all the structural information available in the PDB for UniProt: P62280 (40S ribosomal protein S11) at the PDBe-KB.